1nw4 A 2.2 BS01 IMH A 1 S91 C92 G93 Y160 E182 M183 E184 D206 W212 S89 C90 G91 Y158 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM -logKd/Ki=9.07, Kd=860pM Q8I3X4 14982926 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 B 2.2 BS01 IMH B 1 S91 C92 G93 Y160 E182 M183 E184 D206 S89 C90 G91 Y158 E180 M181 E182 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM -logKd/Ki=9.07, Kd=860pM Q8I3X4 14982926 302 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 C 2.2 BS01 IMH C 1 S91 C92 Y160 E182 M183 E184 D206 W212 S89 C90 Y158 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM Q8I3X4 14982926 303 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 D 2.2 BS01 IMH D 1 S91 C92 G93 Y160 V181 E182 M183 E184 D206 W212 S89 C90 G91 Y158 V179 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM Q8I3X4 14982926 304 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 E 2.2 BS01 IMH E 1 S91 C92 G93 Y160 E182 M183 E184 D206 S89 C90 G91 Y158 E180 M181 E182 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM Q8I3X4 14982926 305 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 F 2.2 BS01 IMH F 1 S91 C92 G93 Y160 E182 M183 E184 D206 W212 S89 C90 G91 Y158 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM Q8I3X4 14982926 306 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA