966c A 1.9 BS01 ZN A 1 H218 H222 H228 H111 H115 H121 H218 E219 H222 H228 H111 E112 H115 H121 3.4.24.7 0004222,0006508,0008237,0008270,0031012 P03956 10074939 265 RWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQ 966c A 1.9 BS02 ZN A 2 H168 D170 H183 H196 H61 D63 H76 H89 H218 E219 H222 H228 H111 E112 H115 H121 3.4.24.7 0004222,0006508,0008237,0008270,0031012 P03956 10074939 266 RWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQ 966c A 1.9 BS03 CA A 1 D175 G176 P177 G178 N180 D198 E201 D68 G69 P70 G71 N73 D91 E94 H218 E219 H222 H228 H111 E112 H115 H121 3.4.24.7 0004222,0006508,0008237,0008270,0031012 P03956 10074939 267 RWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQ 966c A 1.9 BS04 CA A 2 D158 G190 G192 D194 D51 G83 G85 D87 H218 E219 H222 H228 H111 E112 H115 H121 3.4.24.7 0004222,0006508,0008237,0008270,0031012 P03956 10074939 268 RWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQ 966c A 1.9 BS05 CA A 3 D124 E199 E201 D17 E92 E94 H218 E219 H222 H228 H111 E112 H115 H121 3.4.24.7 0004222,0006508,0008237,0008270,0031012 P03956 10074939 269 RWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQ 966c A 1.9 BS06 RS2 A 1 N180 L181 H218 E219 H222 H228 L235 Y237 S239 T241 N73 L74 H111 E112 H115 H121 L128 Y130 S132 T134 H218 E219 H222 H228 H111 E112 H115 H121 3.4.24.7 0004222,0006508,0008237,0008270,0031012 Ki=23nM -logKd/Ki=7.64, Ki=23nM Ki=23nM P03956 10074939 1 RWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQ