8z99 A 3.2 BS01 rna M 0 T20 E22 P50 K52 G53 A54 P80 G91 S92 M93 A96 G174 G175 W176 N178 T19 E21 P30 K32 G33 A34 P60 G71 S72 M73 A76 G137 G138 W139 N141 39143216 -9 ~ 45 AKTMKKIYVTMKTLSPLYTGEVRRNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 A 3.2 BS02 ZN A 1 C71 C81 C87 C51 C61 C67 39143216 301 AKTMKKIYVTMKTLSPLYTGEVRRNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 B 3.2 BS01 rna M 0 T20 G21 F37 R40 P50 K52 A54 R56 S57 G91 S92 M93 G94 A96 T118 H119 L120 R121 I122 R124 K127 F133 G174 G175 W176 L177 N178 T19 G20 F36 R39 P49 K51 A53 R55 S56 G90 S91 M92 G93 A95 T117 H118 L119 R120 I121 R123 K126 F132 G173 G174 W175 L176 N177 39143216 -9 ~ 45 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 B 3.2 BS02 rna N 0 N36 F37 R77 M93 D131 F133 N35 F36 R76 M92 D130 F132 39143216 -16 ~ 37 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 B 3.2 BS03 ZN B 1 C71 C81 C84 C87 C70 C80 C83 C86 39143216 301 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 C 3.2 BS01 rna M 0 T20 G21 E22 K28 F37 K52 G53 R56 S57 P80 G91 S92 M93 A96 T118 H119 L120 R121 I122 R124 K127 F133 G174 W176 N178 T19 G20 E21 K27 F36 K51 G52 R55 S56 P79 G90 S91 M92 A95 T117 H118 L119 R120 I121 R123 K126 F132 G173 W175 N177 39143216 -9 ~ 45 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 C 3.2 BS02 rna N 0 N36 F37 R77 T118 D131 T132 F133 K134 N35 F36 R76 T117 D130 T131 F132 K133 39143216 -16 ~ 37 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 C 3.2 BS03 ZN C 1 C81 C84 C87 C80 C83 C86 39143216 301 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 D 3.2 BS01 rna M 0 G21 E22 F37 R40 K52 G53 R56 S57 P80 G91 S92 M93 R95 A96 T118 H119 L120 R121 I122 R124 K127 A129 F133 G175 K179 G20 E21 F36 R39 K51 G52 R55 S56 P79 G90 S91 M92 R94 A95 T117 H118 L119 R120 I121 R123 K126 A128 F132 G174 K178 39143216 -9 ~ 45 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 D 3.2 BS02 rna N 0 N36 F37 R77 T118 D131 T132 F133 K134 N35 F36 R76 T117 D130 T131 F132 K133 39143216 -16 ~ 37 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 D 3.2 BS03 ZN D 1 C71 C81 C84 C87 C70 C80 C83 C86 39143216 301 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 E 3.2 BS01 rna M 0 G21 F37 R40 K52 G53 T73 G91 S92 M93 A96 T118 H119 L120 R121 I122 R124 F133 G175 W176 N178 G20 F36 R39 K51 G52 T72 G90 S91 M92 A95 T117 H118 L119 R120 I121 R123 F132 G174 W175 N177 39143216 -9 ~ 45 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 E 3.2 BS02 rna N 0 N36 F37 R77 M93 T118 T132 F133 K134 N35 F36 R76 M92 T117 T131 F132 K133 39143216 -16 ~ 37 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 E 3.2 BS03 ZN E 1 C71 C81 C70 C80 39143216 301 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 F 3.2 BS01 rna M 0 G21 E22 F37 R40 P50 K52 G53 R56 G91 S92 M93 T118 H119 L120 R121 I122 R124 K127 F133 G174 G175 W176 N178 G19 E20 F35 R38 P48 K50 G51 R54 G89 S90 M91 T116 H117 L118 R119 I120 R122 K125 F131 G172 G173 W174 N176 39143216 -9 ~ 45 KTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATD 8z99 F 3.2 BS02 rna N 0 N36 F37 R77 R79 M93 D131 T132 F133 K134 N34 F35 R75 R77 M91 D129 T130 F131 K132 39143216 -16 ~ 37 KTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATD 8z99 F 3.2 BS03 ZN F 1 C71 C81 C84 C87 C69 C79 C82 C85 39143216 301 KTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATD 8z99 G 3.2 BS01 rna M 0 P17 L18 R30 H31 G34 A35 G37 Y38 F41 F51 L52 M101 A102 R103 L105 Y144 L145 G146 N147 K148 V149 S150 V190 S192 K193 K194 F201 P17 L18 R30 H31 G34 A35 G37 Y38 F41 F51 L52 M101 A102 R103 L105 Y144 L145 G146 N147 K148 V149 S150 V180 S182 K183 K184 F191 39143216 -9 ~ 45 MKEIKGILESITGFSIPLDNGEYALYPAGRHLRGAIGYIAFNLDLPISSKFLDFDFDDIIFRDLLPISKCGKIFYPEKNSNSLKCPSCNEIYGSSVLRNIMARGLSYKEVIEGKKYRLSIIVKDEKYLNEMEAIIRYILSYGIYLGNKVSKGYGKFKIKEYSIVDILVLLLSDAIEKDIVFSKKEISSSKFEIIRKRGKAKGDFGEIISL 8z99 H 3.2 BS01 rna N 0 E32 Q33 H64 L65 D99 F100 I103 Y198 F230 A231 R234 S255 P256 M257 N294 N297 A314 S315 G316 M317 E319 G320 G321 R322 L324 N325 Y343 H373 S527 K528 N529 R530 N556 N558 T559 R561 N563 N565 K608 E32 Q33 H64 L65 D99 F100 I103 Y198 F227 A228 R231 S252 P253 M254 N291 N294 A311 S312 G313 M314 E316 G317 G318 R319 L321 N322 Y340 H370 S500 K501 N502 R503 N529 N531 T532 R534 N536 N538 K581 39143216 -16 ~ 37 MIKFIGGASKVTGSAFLLETGNAKILIDCGIEQEKGIEKDNNEIIEKKINEIGKADICILTHAHLAASGLVPLLVKKRKVNKIISTPATKELCRLLFNDFQRIQEENNDIPLYSYDDIESSFEIWDEIDDRNTIELFDTKITFYNNSHIIGSVSVFIETHNGNYLFSGDIGSKLQQLMDYPPDMPDGNVDYLILESTYSHDSSDRDRLLEIAKTTCENGGKVLIPSFAIGRLQEVLYTFSNYNFNFPVYIDSPMGSKVTNLIKEYNIYLKKKLRRLSITDDLFNNKYIAINTSNQSKELSNSKEPAVIISASGMLEGGRILNHLEQIKNDENSTLIFVGYQAQNTRGRKILDGEEKVRCRIEKLNSFSAHADQDELIDYIERLKYTPYKVFLVHGEKEQREILAKRIISKKIRVELPENYEILIEKKVVLNINTDNMCNFASYRLMPFSGFIVEKDDRIEINDKNWFDMIWNEEYMALPDMSHDKIIENIEYLFNIKILSKNRIKEFWEEFCKGQKAAIKYITQVHRKNPNTGRRNWNPPEGDFTDNEIEKLYETAYNTLLSLIKYDKNKVYNILINFNPKL 8z99 H 3.2 BS02 ZN H 1 H62 H64 H148 H62 H64 H148 39143216 701 MIKFIGGASKVTGSAFLLETGNAKILIDCGIEQEKGIEKDNNEIIEKKINEIGKADICILTHAHLAASGLVPLLVKKRKVNKIISTPATKELCRLLFNDFQRIQEENNDIPLYSYDDIESSFEIWDEIDDRNTIELFDTKITFYNNSHIIGSVSVFIETHNGNYLFSGDIGSKLQQLMDYPPDMPDGNVDYLILESTYSHDSSDRDRLLEIAKTTCENGGKVLIPSFAIGRLQEVLYTFSNYNFNFPVYIDSPMGSKVTNLIKEYNIYLKKKLRRLSITDDLFNNKYIAINTSNQSKELSNSKEPAVIISASGMLEGGRILNHLEQIKNDENSTLIFVGYQAQNTRGRKILDGEEKVRCRIEKLNSFSAHADQDELIDYIERLKYTPYKVFLVHGEKEQREILAKRIISKKIRVELPENYEILIEKKVVLNINTDNMCNFASYRLMPFSGFIVEKDDRIEINDKNWFDMIWNEEYMALPDMSHDKIIENIEYLFNIKILSKNRIKEFWEEFCKGQKAAIKYITQVHRKNPNTGRRNWNPPEGDFTDNEIEKLYETAYNTLLSLIKYDKNKVYNILINFNPKL 8z99 I 3.2 BS01 rna N 0 S527 K528 N529 R530 N556 N558 N565 S80 K81 N82 R83 N109 N111 N118 39143216 -16 ~ 37 KVVLNINTDNMCNFASYRLMPFSGFIVEKDDRIEINDKNWFDMIWNEEYNKMRSQIALPDMSHDKIIENIEYLFNIKILSKNRIKEFWEEFCKGQKAAIKYITQVHRKNPNTGRRNWNPPEGDFTDNEIEKLYETAYNTLLSLIKYDKNKVYNILINFNP 8z99 J 3.2 BS01 rna M 0 G21 E22 F37 R40 K52 G53 R56 S57 P80 G91 S92 M93 A96 H119 L120 R121 I122 R124 K127 D131 F133 G175 W176 L177 N178 G20 E21 F36 R39 K51 G52 R55 S56 P79 G90 S91 M92 A95 H118 L119 R120 I121 R123 K126 D130 F132 G174 W175 L176 N177 39143216 -9 ~ 45 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 J 3.2 BS02 rna N 0 N36 F37 R77 T118 T132 F133 K134 N35 F36 R76 T117 T131 F132 K133 39143216 -16 ~ 37 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 J 3.2 BS03 ZN J 1 C71 C81 C84 C87 C70 C80 C83 C86 39143216 301 AKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK 8z99 K 3.2 BS01 rna N 0 S527 K528 N529 R530 N558 R561 N565 K608 S290 K291 N292 R293 N321 R324 N328 K371 39143216 -16 ~ 37 MIKFIGAFLLETAKILIDNNEIIEKKINEIGKADICILTHAHLAASGLVPLLVKKRKVNKIISTPATKELCRLLFNDFQRIQEYSYDDIESSFEIWDEIDDRNTIELTKITFYNNSVSVFIETHNGNYLFSGDIGYPPDMPDGNVDYLILESTQDELIDYIERLKYTPYKVFLVHGEKEQREILAKRIISKKIRVELPEKKVVLNINTDNMCNFASYRLMPFSGFIVEKDDRIEINDKNWFDMIWNEEYNKMRSQIVAEDFSTDQMALPDMSHDKIIENIEYLFNIKILSKNRIKEFWEEFCKGQKAAIKYITQVHRKNPNTGRRNWNPPEGDFTDNEIEKLYETAYNTLLSLIKYDKNKVYNILINFNPKL 8z99 L 3.2 BS01 rna N 0 S527 K528 N529 R530 N556 N558 N565 S78 K79 N80 R81 N107 N109 N116 39143216 -16 ~ 37 KKVVLNINTDNMCNFASYRLMPFSGFIVEKDDRIEINDKNWFDMIWNEEYNKMRSQPDMSHDKIIENIEYLFNIKILSKNRIKEFWEEFCKGQKAAIKYITQVHRKNPNTGRRNWNPPEGDFTDNEIEKLYETAYNTLLSLIKYDKNKVYNILINFNPKL 8z99 P 3.2 BS01 rna M 0 G21 V23 F37 R40 P50 K52 G53 A54 R56 G74 F90 G91 S92 M93 R95 T118 H119 L120 R121 I122 R124 K127 F133 G174 N178 G19 V21 F35 R38 P48 K50 G51 A52 R54 G72 F88 G89 S90 M91 R93 T116 H117 L118 R119 I120 R122 K125 F131 G172 N176 39143216 -9 ~ 45 KTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATD 8z99 P 3.2 BS02 rna N 0 N36 F37 T118 D131 T132 F133 K134 N34 F35 T116 D129 T130 F131 K132 39143216 -16 ~ 37 KTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATD 8z99 P 3.2 BS03 ZN P 1 C81 C84 C87 C79 C82 C85 39143216 301 KTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATD