8wt8 A 2.9 BS01 rna E 0 A61 G63 T64 N84 P85 D143 Q147 N150 R151 T154 R221 F222 H224 R226 Q227 F231 P236 R250 M251 K253 A254 G255 H256 V257 R260 R261 Y264 R283 K289 K292 V293 G296 A297 R300 K301 G308 V309 K311 S312 F316 D317 R320 H321 A58 G60 T61 N81 P82 D140 Q144 N147 R148 T151 R218 F219 H221 R223 Q224 F228 P233 R235 M236 K238 A239 G240 H241 V242 R245 R246 Y249 R268 K274 K277 V278 G281 A282 R285 K286 G293 V294 K296 S297 F301 D302 R305 H306 A0A2X3M8B0 38926616 37 ~ 95 ELHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 A 2.9 BS02 rna F 0 R27 H28 R29 T30 R98 N99 R24 H25 R26 T27 R95 N96 A0A2X3M8B0 38926616 110 ~ 177 ELHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 A 2.9 BS03 dna G 0 R250 Y264 M268 S272 K273 G291 L295 R235 Y249 M253 S257 K258 G276 L280 A0A2X3M8B0 38926616 10 ~ 38 ELHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 A 2.9 BS04 dna H 0 T146 G203 I204 G205 K207 T208 M265 V269 K273 T143 G200 I201 G202 K204 T205 M250 V254 K258 A0A2X3M8B0 38926616 3 ~ 29 ELHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 A 2.9 BS05 dna I 0 A13 K14 E60 T62 Y65 P85 K89 R237 R250 K253 A254 A10 K11 E57 T59 Y62 P82 K86 R234 R235 K238 A239 A0A2X3M8B0 38926616 5 ~ 31 ELHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 A 2.9 BS06 MG I 1 D11 E60 D8 E57 A0A2X3M8B0 38926616 101 ELHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 B 2.9 BS01 rna E 0 A61 T62 G63 N84 Q147 N150 R151 T154 R221 F222 H224 R226 Q227 F231 T235 P236 R238 S249 R250 M251 K253 A254 G255 H256 R260 R261 Y264 R283 K289 K290 K292 V293 G296 A297 R300 K301 G308 V309 S312 F316 D317 R320 H321 A58 T59 G60 N81 Q144 N147 R148 T151 R218 F219 H221 R223 Q224 F228 T232 P233 R235 S246 R247 M248 K250 A251 G252 H253 R257 R258 Y261 R280 K286 K287 K289 V290 G293 A294 R297 K298 G305 V306 S309 F313 D314 R317 H318 A0A2X3M8B0 38926616 37 ~ 95 ELHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRYESGSSVRGASRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 B 2.9 BS02 rna F 0 L97 R98 K100 R107 L94 R95 K97 R104 A0A2X3M8B0 38926616 110 ~ 177 ELHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRYESGSSVRGASRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 B 2.9 BS03 dna H 0 K14 T62 N84 P85 K89 K253 Y264 M268 S272 G291 L295 K11 T59 N81 P82 K86 K250 Y261 M265 S269 G288 L292 A0A2X3M8B0 38926616 3 ~ 29 ELHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRYESGSSVRGASRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 B 2.9 BS04 dna I 0 E153 P202 G203 I204 G205 K207 T208 M265 V269 K273 E150 P199 G200 I201 G202 K204 T205 M262 V266 K270 A0A2X3M8B0 38926616 5 ~ 31 ELHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRYESGSSVRGASRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 C 2.9 BS01 rna E 0 L97 R98 N99 L93 R94 N95 A0A2X3M8B0 38926616 37 ~ 95 LHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 C 2.9 BS02 rna F 0 A61 G63 N84 P85 D143 Q147 N150 R151 T154 R221 F222 H224 R226 Q227 F231 T235 P236 R250 M251 K253 A254 G255 H256 R260 R261 Y264 R283 K289 K290 K292 V293 G296 A297 R300 K301 G308 V309 K311 S312 F316 D317 R320 H321 A57 G59 N80 P81 D139 Q143 N146 R147 T150 R217 F218 H220 R222 Q223 F227 T231 P232 R234 M235 K237 A238 G239 H240 R244 R245 Y248 R267 K273 K274 K276 V277 G280 A281 R284 K285 G292 V293 K295 S296 F300 D301 R304 H305 A0A2X3M8B0 38926616 110 ~ 177 LHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 C 2.9 BS03 dna G 0 A13 K14 T62 P85 K89 R250 K253 A254 A9 K10 T58 P81 K85 R234 K237 A238 A0A2X3M8B0 38926616 10 ~ 38 LHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 C 2.9 BS04 dna I 0 Y264 M268 S272 G291 L295 Y248 M252 S256 G275 L279 A0A2X3M8B0 38926616 5 ~ 31 LHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 C 2.9 BS05 dna J 0 N150 P202 G203 G205 K207 T208 M265 V269 K273 N146 P198 G199 G201 K203 T204 M249 V253 K257 A0A2X3M8B0 38926616 12 ~ 40 LHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 D 2.9 BS01 rna F 0 A61 G63 N84 Q147 N150 R151 T154 R221 F222 H224 R226 Q227 F231 T235 P236 R238 S249 M251 K253 A254 G255 H256 V257 R260 R261 Y264 R283 K289 K290 K292 V293 G296 A297 R300 K301 G308 V309 F316 D317 R320 H321 A57 G59 N80 Q143 N146 R147 T150 R217 F218 H220 R222 Q223 F227 T231 P232 R234 S245 M247 K249 A250 G251 H252 V253 R256 R257 Y260 R279 K285 K286 K288 V289 G292 A293 R296 K297 G304 V305 F312 D313 R316 H317 A0A2X3M8B0 38926616 110 ~ 177 LHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRYESGSSVRGASRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 D 2.9 BS02 dna G 0 E153 P202 G203 G205 K207 T208 M265 V269 K273 E149 P198 G199 G201 K203 T204 M261 V265 K269 A0A2X3M8B0 38926616 10 ~ 38 LHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRYESGSSVRGASRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 D 2.9 BS03 dna H 0 R246 A248 R242 A244 A0A2X3M8B0 38926616 3 ~ 29 LHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRYESGSSVRGASRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 D 2.9 BS04 dna I 0 S241 S244 S237 S240 A0A2X3M8B0 38926616 5 ~ 31 LHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRYESGSSVRGASRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH 8wt8 D 2.9 BS05 dna J 0 K14 N84 P85 R250 Y264 M268 S272 K273 G291 L295 K10 N80 P81 R246 Y260 M264 S268 K269 G287 L291 A0A2X3M8B0 38926616 12 ~ 40 LHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRYESGSSVRGASRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRH