7rlj A 3.8 BS01 AGS A 1 G248 T249 G250 K251 T252 L253 H384 G228 T229 G230 K231 T232 L233 H364 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 801 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj A 3.8 BS02 JDP A 1 V474 D478 I479 L526 A685 V454 D458 I459 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj B 3.8 BS01 AGS B 1 G248 T249 G250 K251 T252 L253 H384 G228 T229 G230 K231 T232 L233 H364 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 801 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj B 3.8 BS02 JDP B 1 V474 D478 I479 G523 L526 A685 V454 D458 I459 G503 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj C 3.8 BS01 AGS C 1 G248 T249 G250 K251 T252 L253 H384 G228 T229 G230 K231 T232 L233 H364 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 801 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj C 3.8 BS02 JDP C 1 V474 I479 L526 A685 V454 I459 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj D 3.8 BS01 AGS D 1 G248 T249 G250 K251 T252 L253 H384 G228 T229 G230 K231 T232 L233 H364 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 801 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj D 3.8 BS02 JDP D 1 V474 D478 I479 L526 A685 V454 D458 I459 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj E 3.8 BS01 AGS E 1 G248 T249 G250 K251 T252 L253 H384 G228 T229 G230 K231 T232 L233 H364 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 801 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj E 3.8 BS02 JDP E 1 V474 I479 G521 C522 G523 L526 G684 A685 V454 I459 G501 C502 G503 L506 G664 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj F 3.8 BS01 AGS F 1 G248 T249 G250 K251 T252 L253 H384 G228 T229 G230 K231 T232 L233 H364 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 801 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj F 3.8 BS02 JDP F 1 V474 D478 I479 G523 L526 A685 V454 D458 I459 G503 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj G 3.8 BS01 AGS G 1 G248 T249 G250 K251 T252 L253 H384 G228 T229 G230 K231 T232 L233 H364 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 801 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj G 3.8 BS02 JDP G 1 V474 D478 I479 L526 A685 V454 D458 I459 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj H 3.8 BS01 AGS H 1 G248 T249 G250 K251 T252 L253 H384 G228 T229 G230 K231 T232 L233 H364 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 801 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj H 3.8 BS02 JDP H 1 V474 D478 I479 G523 L526 A685 V454 D458 I459 G503 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj I 3.8 BS01 AGS I 1 G248 T249 G250 K251 T252 L253 H384 G228 T229 G230 K231 T232 L233 H364 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 801 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj I 3.8 BS02 JDP I 1 V474 D478 I479 G523 L526 A685 V454 D458 I459 G503 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj J 3.8 BS01 AGS J 1 G248 T249 G250 K251 T252 L253 H384 G228 T229 G230 K231 T232 L233 H364 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 801 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj J 3.8 BS02 JDP J 1 V474 D478 I479 L526 A685 V454 D458 I459 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj K 3.8 BS01 AGS K 1 G248 T249 G250 K251 T252 L253 H384 G228 T229 G230 K231 T232 L233 H364 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 801 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj K 3.8 BS02 JDP K 1 V474 D478 I479 G523 L526 A685 V454 D458 I459 G503 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj L 3.8 BS01 AGS L 1 G248 T249 G250 K251 T252 L253 H384 G228 T229 G230 K231 T232 L233 H364 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 801 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj L 3.8 BS02 JDP L 1 V474 D478 I479 L526 A685 V454 D458 I459 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF