7rli A 3.1 BS01 JDP A 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli A 3.1 BS02 ADP A 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 902 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli B 3.1 BS01 JDP B 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli B 3.1 BS02 ADP B 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 A412 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 A392 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 902 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli C 3.1 BS01 JDP C 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli C 3.1 BS02 ADP C 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 902 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli D 3.1 BS01 JDP D 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli D 3.1 BS02 ADP D 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 902 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli E 3.1 BS01 JDP E 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli E 3.1 BS02 ADP E 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 902 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli F 3.1 BS01 JDP F 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli F 3.1 BS02 ADP F 1 I206 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 I186 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 902 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli G 3.1 BS01 JDP G 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli G 3.1 BS02 ADP G 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 902 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli H 3.1 BS01 JDP H 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli H 3.1 BS02 ADP H 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 902 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli I 3.1 BS01 JDP I 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli I 3.1 BS02 ADP I 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 902 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli J 3.1 BS01 JDP J 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli J 3.1 BS02 ADP J 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 902 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli K 3.1 BS01 JDP K 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli K 3.1 BS02 ADP K 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 902 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli L 3.1 BS01 JDP L 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli L 3.1 BS02 ADP L 1 D205 G207 G248 G250 K251 T252 L253 I380 H384 G408 A409 D185 G187 G228 G230 K231 T232 L233 I360 H364 G388 A389 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 34520757 902 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS