7oma A 3.1 BS01 rna E 0 K266 R269 R280 Y349 D351 D352 T438 T443 D447 L513 M540 R545 D563 R564 G567 T571 K252 R255 R266 Y335 D337 D338 T424 T429 D433 L499 M526 R531 D544 R545 G548 T552 ? Q6A562 34203380 3 ~ 9 RLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI 7oma A 3.1 BS02 rna F 0 Y153 A214 S215 K224 K264 K266 Y282 S294 Y317 G318 F319 S320 T322 Y349 G439 Y139 A200 S201 K210 K250 K252 Y268 S280 Y303 G304 F305 S306 T308 Y335 G425 ? Q6A562 34203380 1 ~ 8 RLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI 7oma A 3.1 BS03 POP A 1 R280 Q372 M373 R266 Q358 M359 ? Q6A562 34203380 701 RLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI 7oma A 3.1 BS04 MG A 1 D351 D369 F370 D337 D355 F356 ? Q6A562 34203380 702 RLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI 7oma B 3.1 BS01 rna G 0 K266 R280 Y349 D351 D374 T438 T443 D447 L513 M540 R545 D563 R564 G567 L568 T571 K252 R266 Y335 D337 D360 T424 T429 D433 L499 M526 R531 D544 R545 G548 L549 T552 ? Q6A562 34203380 3 ~ 9 RLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVV 7oma B 3.1 BS02 rna H 0 I213 A214 S215 K224 K264 K266 Y282 F283 S294 Y317 G318 S320 T322 Y349 G439 V441 W633 I199 A200 S201 K210 K250 K252 Y268 F269 S280 Y303 G304 S306 T308 Y335 G425 V427 W591 ? Q6A562 34203380 1 ~ 8 RLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVV 7oma B 3.1 BS03 POP B 1 R164 R280 F370 K371 Q372 M373 K488 R150 R266 F356 K357 Q358 M359 K474 ? Q6A562 34203380 701 RLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVV 7oma B 3.1 BS04 MG B 1 D352 D369 D338 D355 ? Q6A562 34203380 702 RLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVV 7oma B 3.1 BS05 MG B 2 D351 D369 F370 D337 D355 F356 ? Q6A562 34203380 703 RLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVV 7oma C 3.1 BS01 rna I 0 K266 R269 R280 Y349 D351 D352 D374 T438 T443 D447 L513 M540 R545 D563 R564 G567 L568 T571 Q600 K253 R256 R267 Y336 D338 D339 D361 T425 T430 D434 L500 M527 R532 D545 R546 G549 L550 T553 Q582 ? Q6A562 34203380 3 ~ 9 TRLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVV 7oma C 3.1 BS02 rna J 0 A214 S215 K224 K264 K266 Y282 S284 S294 Y317 G318 S320 Y349 G439 V441 T444 L637 A201 S202 K211 K251 K253 Y269 S271 S281 Y304 G305 S307 Y336 G426 V428 T431 L596 ? Q6A562 34203380 1 ~ 8 TRLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVV 7oma C 3.1 BS03 POP C 1 R280 D351 D369 F370 Q372 K488 R267 D338 D356 F357 Q359 K475 ? Q6A562 34203380 701 TRLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVV 7oma D 3.1 BS01 rna L 0 K266 R269 R280 Y349 D351 D374 T443 T444 D447 M540 R545 D563 R564 K253 R256 R267 Y336 D338 D361 T430 T431 D434 M527 R532 D545 R546 ? Q6A562 34203380 3 ~ 9 RLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGVSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI 7oma D 3.1 BS02 rna K 0 A214 K224 K264 K266 T267 Y282 S294 Y317 G318 S320 T322 Y349 G439 V441 W633 L637 A201 K211 K251 K253 T254 Y269 S281 Y304 G305 S307 T309 Y336 G426 V428 W592 L596 ? Q6A562 34203380 1 ~ 8 RLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGVSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI