7om7 A 2.4 BS01 rna E 0 R269 Y349 D351 L513 M540 R545 D563 R564 G567 L568 T571 Q600 R255 Y335 D337 L499 M526 R531 D543 R544 G547 L548 T551 Q580 ? Q6A562 34203380 3 ~ 8 TRLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAASDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSTETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI 7om7 A 2.4 BS02 rna F 0 Y153 N211 A214 S215 K224 K264 Y282 S284 S294 Q298 Y317 G318 S320 G439 V441 W633 Y139 N197 A200 S201 K210 K250 Y268 S270 S280 Q284 Y303 G304 S306 G425 V427 W590 ? Q6A562 34203380 1 ~ 8 TRLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAASDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSTETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI 7om7 A 2.4 BS03 2KH A 1 K266 R280 Q372 D374 T438 T443 D447 K488 K252 R266 Q358 D360 T424 T429 D433 K474 ? Q6A562 34203380 701 TRLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAASDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSTETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI 7om7 B 2.4 BS01 rna G 0 R269 Y349 D351 D352 L513 M540 R545 D563 R564 G567 L568 T571 R256 Y336 D338 D339 L500 M527 R532 D545 R546 G549 L550 T553 ? Q6A562 34203380 3 ~ 8 TRLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI 7om7 B 2.4 BS02 rna H 0 I213 A214 S215 K224 K264 Y282 S284 S294 Q298 Y317 G318 S320 Y349 G439 I200 A201 S202 K211 K251 Y269 S271 S281 Q285 Y304 G305 S307 Y336 G426 ? Q6A562 34203380 1 ~ 8 TRLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI 7om7 B 2.4 BS03 2KH B 1 R164 K266 K278 R280 D351 Q372 M373 D374 T438 D447 K488 R151 K253 K265 R267 D338 Q359 M360 D361 T425 D434 K475 ? Q6A562 34203380 701 TRLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI 7om7 C 2.4 BS01 rna I 0 A214 S215 K224 K264 Y282 F283 S294 Q298 Y317 G318 S320 T322 G439 V441 W633 A201 S202 K211 K251 Y269 F270 S281 Q285 Y304 G305 S307 T309 G426 V428 W594 ? Q6A562 34203380 1 ~ 8 TRLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSRSKETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI 7om7 C 2.4 BS02 rna J 0 R269 Y349 G350 D351 D352 L513 M540 R545 D563 R564 G567 L568 T571 V599 R256 Y336 G337 D338 D339 L500 M527 R532 D548 R549 G552 L553 T556 V584 ? Q6A562 34203380 2 ~ 8 TRLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSRSKETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI 7om7 D 2.4 BS01 rna K 0 S215 K224 K264 K266 Y282 F283 S284 Q298 Y317 G318 S320 T322 G439 V441 W633 S202 K211 K251 K253 Y269 F270 S271 Q285 Y304 G305 S307 T309 G426 V428 W591 ? Q6A562 34203380 1 ~ 8 TRLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAATSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI 7om7 D 2.4 BS02 rna L 0 R269 Y349 G350 D351 L513 M540 R545 D563 R564 G567 L568 T571 R256 Y336 G337 D338 L500 M527 R532 D545 R546 G549 L550 T553 ? Q6A562 34203380 3 ~ 8 TRLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQARSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHNNNGKVSVKRQFAATSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQRLKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIASAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECKNKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSFNAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLYRICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEMATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMFGSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLGLQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLLVTGAVFDERARGLMGAVINSTAPEVVCMRVISDGYPSYDWVVSLYSRDHPCDMPRVFPEAATLIASYRKQVMDTRVVI