7ni4 A 3.0 BS01 ZN A 1 H1876 H1895 C1899 C1900 H364 H365 C369 C370 2.7.11.1 0000077,0000425,0000723,0000724,0000729,0000781,0001541,0001666,0001756,0002331,0002376,0003677,0004672,0004674,0004677,0005515,0005524,0005634,0005654,0005730,0005737,0005777,0005782,0005813,0005819,0005829,0005856,0006281,0006302,0006303,0006338,0006468,0006974,0006977,0007094,0007095,0007131,0007140,0007143,0007165,0007292,0007420,0007507,0008340,0008585,0008630,0009791,0010212,0010506,0010628,0016301,0016303,0016310,0018105,0030335,0030889,0031410,0032210,0032212,0033151,0033554,0034614,0035264,0035861,0035979,0036092,0036289,0042159,0042770,0042802,0042981,0043065,0043231,0043517,0043525,0044024,0044877,0045141,0045785,0045944,0046777,0048538,0048599,0051402,0051726,0070192,0071044,0071300,0071479,0071480,0071481,0071500,0080090,0080135,0090398,0090399,0097694,0097695,0098850,0106310,1900034,1901796,1903626,1903978,1904262,1904354,1904358,1904884,1990391,2000785 Q13315 34556870 3201 LENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVASDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 7ni4 A 3.0 BS02 UGK A 1 A2693 L2715 K2717 Y2755 L2767 W2769 C2770 T2773 P2775 L2877 I2888 A1096 L1118 K1120 Y1158 L1170 W1172 C1173 T1176 P1178 L1280 I1291 2.7.11.1 0000077,0000425,0000723,0000724,0000729,0000781,0001541,0001666,0001756,0002331,0002376,0003677,0004672,0004674,0004677,0005515,0005524,0005634,0005654,0005730,0005737,0005777,0005782,0005813,0005819,0005829,0005856,0006281,0006302,0006303,0006338,0006468,0006974,0006977,0007094,0007095,0007131,0007140,0007143,0007165,0007292,0007420,0007507,0008340,0008585,0008630,0009791,0010212,0010506,0010628,0016301,0016303,0016310,0018105,0030335,0030889,0031410,0032210,0032212,0033151,0033554,0034614,0035264,0035861,0035979,0036092,0036289,0042159,0042770,0042802,0042981,0043065,0043231,0043517,0043525,0044024,0044877,0045141,0045785,0045944,0046777,0048538,0048599,0051402,0051726,0070192,0071044,0071300,0071479,0071480,0071481,0071500,0080090,0080135,0090398,0090399,0097694,0097695,0098850,0106310,1900034,1901796,1903626,1903978,1904262,1904354,1904358,1904884,1990391,2000785 IC50=<1.000nM Q13315 34556870 3202 LENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVASDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 7ni4 B 3.0 BS01 ZN B 1 H1876 H1895 C1899 C1900 H364 H365 C369 C370 2.7.11.1 0000077,0000425,0000723,0000724,0000729,0000781,0001541,0001666,0001756,0002331,0002376,0003677,0004672,0004674,0004677,0005515,0005524,0005634,0005654,0005730,0005737,0005777,0005782,0005813,0005819,0005829,0005856,0006281,0006302,0006303,0006338,0006468,0006974,0006977,0007094,0007095,0007131,0007140,0007143,0007165,0007292,0007420,0007507,0008340,0008585,0008630,0009791,0010212,0010506,0010628,0016301,0016303,0016310,0018105,0030335,0030889,0031410,0032210,0032212,0033151,0033554,0034614,0035264,0035861,0035979,0036092,0036289,0042159,0042770,0042802,0042981,0043065,0043231,0043517,0043525,0044024,0044877,0045141,0045785,0045944,0046777,0048538,0048599,0051402,0051726,0070192,0071044,0071300,0071479,0071480,0071481,0071500,0080090,0080135,0090398,0090399,0097694,0097695,0098850,0106310,1900034,1901796,1903626,1903978,1904262,1904354,1904358,1904884,1990391,2000785 Q13315 34556870 3201 LENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVASDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 7ni4 B 3.0 BS02 UGK B 1 L2715 K2717 Y2755 L2767 E2768 W2769 C2770 T2773 P2775 L2877 I2888 L1118 K1120 Y1158 L1170 E1171 W1172 C1173 T1176 P1178 L1280 I1291 2.7.11.1 0000077,0000425,0000723,0000724,0000729,0000781,0001541,0001666,0001756,0002331,0002376,0003677,0004672,0004674,0004677,0005515,0005524,0005634,0005654,0005730,0005737,0005777,0005782,0005813,0005819,0005829,0005856,0006281,0006302,0006303,0006338,0006468,0006974,0006977,0007094,0007095,0007131,0007140,0007143,0007165,0007292,0007420,0007507,0008340,0008585,0008630,0009791,0010212,0010506,0010628,0016301,0016303,0016310,0018105,0030335,0030889,0031410,0032210,0032212,0033151,0033554,0034614,0035264,0035861,0035979,0036092,0036289,0042159,0042770,0042802,0042981,0043065,0043231,0043517,0043525,0044024,0044877,0045141,0045785,0045944,0046777,0048538,0048599,0051402,0051726,0070192,0071044,0071300,0071479,0071480,0071481,0071500,0080090,0080135,0090398,0090399,0097694,0097695,0098850,0106310,1900034,1901796,1903626,1903978,1904262,1904354,1904358,1904884,1990391,2000785 IC50=<1.000nM Q13315 34556870 3202 LENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVASDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV