7n6q A 3.87 BS01 7T8 A 1 Y391 S430 A431 H434 F438 M449 Q485 Q488 Y492 Y274 S313 A314 H317 F321 M332 Q360 Q363 Y367 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0005903,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0030299,0033344,0034379,0034383,0034736,0042632 IC50=179nM O75908 601 KQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFILLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRAAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMAWNVLMWTMLFLGQGIQVSLYCQEWYARR 7n6q A 3.87 BS02 CLR A 1 F160 F234 E235 A311 C312 F358 W362 F56 F124 E125 A194 C195 F241 W245 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0005903,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0030299,0033344,0034379,0034383,0034736,0042632 O75908 602 KQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFILLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRAAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMAWNVLMWTMLFLGQGIQVSLYCQEWYARR 7n6q A 3.87 BS03 CLR A 2 F120 Y124 F127 I128 C307 L352 F356 W382 F21 Y25 F28 I29 C190 L235 F239 W265 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0005903,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0030299,0033344,0034379,0034383,0034736,0042632 O75908 603 KQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFILLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRAAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMAWNVLMWTMLFLGQGIQVSLYCQEWYARR 7n6q B 3.87 BS01 7T8 B 1 Y391 S430 A431 F438 M449 Q485 Q488 Y492 Y274 S313 A314 F321 M332 Q360 Q363 Y367 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0005903,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0030299,0033344,0034379,0034383,0034736,0042632 IC50=179nM O75908 601 KQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFILLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRAAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMAWNVLMWTMLFLGQGIQVSLYCQEWYARR 7n6q B 3.87 BS02 CLR B 1 F160 F234 E235 A311 C312 W362 F56 F124 E125 A194 C195 W245 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0005903,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0030299,0033344,0034379,0034383,0034736,0042632 O75908 602 KQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFILLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRAAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMAWNVLMWTMLFLGQGIQVSLYCQEWYARR 7n6q B 3.87 BS03 CLR B 2 F120 Y124 F127 I128 C307 L352 F356 W382 F21 Y25 F28 I29 C190 L235 F239 W265 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0005903,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0030299,0033344,0034379,0034383,0034736,0042632 O75908 603 KQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFILLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRAAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMAWNVLMWTMLFLGQGIQVSLYCQEWYARR 7n6q C 3.87 BS01 7T8 C 1 Y391 S430 A431 H434 F438 M449 Q485 Q488 Y492 Y274 S313 A314 H317 F321 M332 Q360 Q363 Y367 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0005903,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0030299,0033344,0034379,0034383,0034736,0042632 IC50=179nM O75908 601 KQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFILLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRAAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMAWNVLMWTMLFLGQGIQVSLYCQEWYARR 7n6q C 3.87 BS02 CLR C 1 F160 F234 E235 A311 C312 F358 W362 F56 F124 E125 A194 C195 F241 W245 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0005903,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0030299,0033344,0034379,0034383,0034736,0042632 O75908 602 KQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFILLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRAAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMAWNVLMWTMLFLGQGIQVSLYCQEWYARR 7n6q C 3.87 BS03 CLR C 2 F120 Y124 F127 I128 C307 L352 F356 W382 F21 Y25 F28 I29 C190 L235 F239 W265 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0005903,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0030299,0033344,0034379,0034383,0034736,0042632 O75908 603 KQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFILLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRAAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMAWNVLMWTMLFLGQGIQVSLYCQEWYARR 7n6q D 3.87 BS01 7T8 D 1 Y391 S430 A431 F438 M449 Q485 Q488 Y492 Y274 S313 A314 F321 M332 Q360 Q363 Y367 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0005903,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0030299,0033344,0034379,0034383,0034736,0042632 IC50=179nM O75908 601 KQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFILLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRAAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMAWNVLMWTMLFLGQGIQVSLYCQEWYARR 7n6q D 3.87 BS02 CLR D 1 F160 F234 E235 A311 C312 W362 F56 F124 E125 A194 C195 W245 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0005903,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0030299,0033344,0034379,0034383,0034736,0042632 O75908 602 KQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFILLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRAAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMAWNVLMWTMLFLGQGIQVSLYCQEWYARR 7n6q D 3.87 BS03 CLR D 2 F120 Y124 F127 I128 C307 L352 F356 W382 F21 Y25 F28 I29 C190 L235 F239 W265 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0005903,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0030299,0033344,0034379,0034383,0034736,0042632 O75908 603 KQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFILLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRAAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMAWNVLMWTMLFLGQGIQVSLYCQEWYARR