7m0v A 3.16 BS01 ANP A 1 G466 S467 F468 A481 K483 W531 C532 K578 N581 F583 D594 G18 S19 F20 A33 K35 W83 C84 K130 N133 F135 D146 D576 K578 N580 N581 D594 S616 D128 K130 N132 N133 D146 S168 2.7.11.1 0004672,0005524,0006468 P15056 34470822 801 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP 7m0v A 3.16 BS02 MG A 1 N580 N581 D594 N132 N133 D146 D576 K578 N580 N581 D594 S616 D128 K130 N132 N133 D146 S168 2.7.11.1 0004672,0005524,0006468 P15056 34470822 802 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP 7m0v B 3.16 BS01 ANP B 1 L74 G75 A76 G77 N78 V82 A95 K97 M143 S150 Q153 L197 L33 G34 A35 G36 N37 V41 A54 K56 M102 S109 Q112 L156 D190 K192 N195 D208 D217 T226 D149 K151 N154 D167 D176 T185 2.7.12.2 0000165,0000187,0004672,0004674,0004708,0004712,0004713,0005078,0005515,0005524,0005634,0005737,0005739,0005769,0005770,0005783,0005794,0005813,0005816,0005829,0005856,0005886,0005925,0006468,0006935,0007165,0007507,0008285,0010628,0014044,0016020,0016310,0021697,0030182,0030216,0030295,0030878,0032872,0035987,0038133,0042552,0043410,0043539,0044342,0045893,0048009,0048538,0048679,0048870,0050772,0060020,0060324,0060425,0060440,0060502,0060674,0060711,0070371,0070374,0071902,0090170,0090398,0097110,0106310,1903226,2000641 Q02750 34470822 801 LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDAMANAFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQ 7m0v B 3.16 BS02 EUI B 1 K97 L115 V127 N195 D208 F209 V211 L215 I216 M219 K56 L74 V86 N154 D167 F168 V170 L174 I175 M178 D190 K192 N195 D208 D217 T226 D149 K151 N154 D167 D176 T185 2.7.12.2 0000165,0000187,0004672,0004674,0004708,0004712,0004713,0005078,0005515,0005524,0005634,0005737,0005739,0005769,0005770,0005783,0005794,0005813,0005816,0005829,0005856,0005886,0005925,0006468,0006935,0007165,0007507,0008285,0010628,0014044,0016020,0016310,0021697,0030182,0030216,0030295,0030878,0032872,0035987,0038133,0042552,0043410,0043539,0044342,0045893,0048009,0048538,0048679,0048870,0050772,0060020,0060324,0060425,0060440,0060502,0060674,0060711,0070371,0070374,0071902,0090170,0090398,0097110,0106310,1903226,2000641 IC50=4.2nM Q02750 34470822 803 LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDAMANAFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQ