7m0t A 3.19 BS01 ANP A 1 G466 S467 F468 A481 K483 W531 K578 N581 F583 D594 G19 S20 F21 A34 K36 W84 K131 N134 F136 D147 D576 K578 N580 N581 D594 S616 D129 K131 N133 N134 D147 S169 2.7.11.1 0004672,0005524,0006468 P15056 34470822 801 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL 7m0t A 3.19 BS02 MG A 1 N581 D594 N134 D147 D576 K578 N580 N581 D594 S616 D129 K131 N133 N134 D147 S169 2.7.11.1 0004672,0005524,0006468 P15056 34470822 802 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL 7m0t B 3.19 BS01 3EW B 1 G79 K97 M143 D208 F209 G210 V211 S212 L215 I216 M219 G38 K56 M102 D167 F168 G169 V170 S171 L174 I175 M178 D190 K192 N195 D208 D217 T226 D149 K151 N154 D167 D176 T185 2.7.12.2 0000165,0000187,0004672,0004674,0004708,0004712,0004713,0005078,0005515,0005524,0005634,0005737,0005739,0005769,0005770,0005783,0005794,0005813,0005816,0005829,0005856,0005886,0005925,0006468,0006935,0007165,0007507,0008285,0010628,0014044,0016020,0016310,0021697,0030182,0030216,0030295,0030878,0032872,0035987,0038133,0042552,0043410,0043539,0044342,0045893,0048009,0048538,0048679,0048870,0050772,0060020,0060324,0060425,0060440,0060502,0060674,0060711,0070371,0070374,0071902,0090170,0090398,0097110,0106310,1903226,2000641 IC50=80nM, Kd=99nM Q02750 34470822 401 LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDAMANAFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQ 7m0t B 3.19 BS02 ANP B 1 G75 A76 G77 N78 V82 K97 M146 S150 Q153 K192 S194 L197 G34 A35 G36 N37 V41 K56 M105 S109 Q112 K151 S153 L156 D190 K192 N195 D208 D217 T226 D149 K151 N154 D167 D176 T185 2.7.12.2 0000165,0000187,0004672,0004674,0004708,0004712,0004713,0005078,0005515,0005524,0005634,0005737,0005739,0005769,0005770,0005783,0005794,0005813,0005816,0005829,0005856,0005886,0005925,0006468,0006935,0007165,0007507,0008285,0010628,0014044,0016020,0016310,0021697,0030182,0030216,0030295,0030878,0032872,0035987,0038133,0042552,0043410,0043539,0044342,0045893,0048009,0048538,0048679,0048870,0050772,0060020,0060324,0060425,0060440,0060502,0060674,0060711,0070371,0070374,0071902,0090170,0090398,0097110,0106310,1903226,2000641 Q02750 34470822 402 LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDAMANAFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQ 7m0t B 3.19 BS03 MG B 1 N195 D208 N154 D167 D190 K192 N195 D208 D217 T226 D149 K151 N154 D167 D176 T185 2.7.12.2 0000165,0000187,0004672,0004674,0004708,0004712,0004713,0005078,0005515,0005524,0005634,0005737,0005739,0005769,0005770,0005783,0005794,0005813,0005816,0005829,0005856,0005886,0005925,0006468,0006935,0007165,0007507,0008285,0010628,0014044,0016020,0016310,0021697,0030182,0030216,0030295,0030878,0032872,0035987,0038133,0042552,0043410,0043539,0044342,0045893,0048009,0048538,0048679,0048870,0050772,0060020,0060324,0060425,0060440,0060502,0060674,0060711,0070371,0070374,0071902,0090170,0090398,0097110,0106310,1903226,2000641 Q02750 34470822 403 LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDAMANAFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQ