7lpe A 3.72 BS01 LBN A 1 N437 V440 F488 F516 Y555 N195 V198 F246 F274 Y313 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 O35433 34239123 1001 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe A 3.72 BS02 6OU A 1 Y631 L635 F638 Y365 L369 F372 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 O35433 34239123 1002 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe A 3.72 BS03 4DY A 1 Y511 S512 T550 Y554 R557 Y269 S270 T308 Y312 R315 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 1003 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe B 3.72 BS01 LBN B 1 N437 V440 F488 F516 Y555 N195 V198 F246 F274 Y313 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 O35433 34239123 1001 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe B 3.72 BS02 6OU B 1 Y631 L635 F638 Y365 L369 F372 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 O35433 34239123 1002 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe B 3.72 BS03 4DY B 1 Y511 S512 T550 Y554 R557 Y269 S270 T308 Y312 R315 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 1003 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe C 3.72 BS01 LBN C 1 N437 V440 F488 F516 Y555 N195 V198 F246 F274 Y313 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 O35433 34239123 1001 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe C 3.72 BS02 6OU C 1 Y631 L635 F638 Y365 L369 F372 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 O35433 34239123 1002 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe C 3.72 BS03 4DY C 1 Y511 S512 T550 Y554 R557 Y269 S270 T308 Y312 R315 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 1003 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe D 3.72 BS01 LBN D 1 N437 V440 F488 F516 Y555 N195 V198 F246 F274 Y313 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 O35433 34239123 1001 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe D 3.72 BS02 6OU D 1 Y631 L635 F638 Y365 L369 F372 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 O35433 34239123 1002 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe D 3.72 BS03 4DY D 1 Y511 S512 T550 Y554 R557 Y269 S270 T308 Y312 R315 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 1003 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW