7lad A 2.65 BS01 HEM A 1 R105 S119 W126 R130 A305 G306 T309 L373 R375 F434 G435 R439 C441 A447 M451 R79 S93 W100 R104 A256 G257 T260 L324 R326 F385 G386 R390 C392 A398 M402 1.14.14.1 0002933,0004497,0005506,0005515,0005783,0005789,0006805,0008202,0008210,0008401,0009822,0016020,0016491,0016705,0016712,0019825,0020037,0042178,0042572,0042573,0043231,0046222,0046872,0050649,0070330,0070989,0101020 P20815 34648292 601 TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKLDFLQLMIDSSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRD 7lad A 2.65 BS02 XRD A 1 F213 F215 F304 A305 A370 R372 E374 G480 L481 F187 F189 F255 A256 A321 R323 E325 G431 L432 1.14.14.1 0002933,0004497,0005506,0005515,0005783,0005789,0006805,0008202,0008210,0008401,0009822,0016020,0016491,0016705,0016712,0019825,0020037,0042178,0042572,0042573,0043231,0046222,0046872,0050649,0070330,0070989,0101020 Kd=100nM, IC50=15600nM P20815 34648292 602 TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKLDFLQLMIDSSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRD