7jxp A 2.16 BS01 ANP A 1 L718 G719 S720 G721 A722 V726 A743 K745 M790 M793 C797 D837 R841 N842 L844 L19 G20 S21 G22 A23 V27 A44 K46 M91 M94 C98 D138 R142 N143 L145 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxp A 2.16 BS02 MG A 1 N842 D855 N143 D156 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1102 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxp A 2.16 BS03 JBJ A 1 V726 A743 I744 K745 L747 I759 M766 R776 L777 L788 M790 D855 F856 L858 L861 L862 E865 V27 A44 I45 K46 L48 I60 M67 R77 L78 L89 M91 D156 F157 L159 L162 L163 E166 2.7.10.1 0004672,0004713,0005524,0006468 IC50=>1000nM P00533 1103 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxp B 2.16 BS01 ANP B 1 L718 G719 G721 A722 V726 A743 K745 M790 M793 C797 D837 R841 N842 L844 L19 G20 G22 A23 V27 A44 K46 M91 M94 C98 D138 R142 N143 L145 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxp B 2.16 BS02 MG B 1 N842 D855 N143 D156 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1102 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxp B 2.16 BS03 JBJ B 1 A743 I744 K745 E749 I759 M766 R776 L777 L788 M790 D855 F856 L858 L861 L862 E865 A44 I45 K46 E50 I60 M67 R77 L78 L89 M91 D156 F157 L159 L162 L163 E166 2.7.10.1 0004672,0004713,0005524,0006468 IC50=>1000nM P00533 1103 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxp C 2.16 BS01 JBJ C 1 F723 V726 A743 I744 K745 I759 E762 M766 R776 L777 L788 M790 D855 F856 L858 F24 V27 A44 I45 K46 I60 E63 M67 R77 L78 L89 M91 D156 F157 L159 2.7.10.1 0004672,0004713,0005524,0006468 IC50=>1000nM P00533 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxp C 2.16 BS02 YY3 C 1 L718 G719 G721 V726 A743 L792 M793 G796 C797 D800 R841 L844 D855 L19 G20 G22 V27 A44 L93 M94 G97 C98 D101 R142 L145 D156 2.7.10.1 0004672,0004713,0005524,0006468 IC50=2.0nM, Ki=14nM, EC50=6.0nM P00533 1102 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxp D 2.16 BS01 ANP D 1 G719 G721 A722 V726 A743 K745 M790 M793 C797 D837 R841 N842 L844 G20 G22 A23 V27 A44 K46 M91 M94 C98 D138 R142 N143 L145 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxp D 2.16 BS02 MG D 1 N842 D855 N143 D156 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1102 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxp D 2.16 BS03 JBJ D 1 V726 A743 I744 K745 L747 I759 M766 R776 L777 L788 M790 D855 F856 L858 V27 A44 I45 K46 L48 I60 M67 R77 L78 L89 M91 D156 F157 L159 2.7.10.1 0004672,0004713,0005524,0006468 IC50=>1000nM P00533 1103 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxp E 2.16 BS01 JBJ E 1 V726 A743 I744 K745 I759 R776 L777 L788 M790 D855 F856 L858 V27 A44 I45 K46 I60 R77 L78 L89 M91 D156 F157 L159 2.7.10.1 0004672,0004713,0005524,0006468 IC50=>1000nM P00533 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDPSPTDSNFYRALMDEEDM 7jxp E 2.16 BS02 YY3 E 1 L718 V726 L792 M793 G796 C797 D800 L844 D855 L19 V27 L93 M94 G97 C98 D101 L145 D156 2.7.10.1 0004672,0004713,0005524,0006468 IC50=2.0nM, Ki=14nM, EC50=6.0nM P00533 1102 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDPSPTDSNFYRALMDEEDM 7jxp F 2.16 BS01 ANP F 1 G719 S720 G721 A722 V726 A743 K745 M790 M793 C797 D837 R841 N842 L844 G20 S21 G22 A23 V27 A44 K46 M91 M94 C98 D138 R142 N143 L145 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxp F 2.16 BS02 MG F 1 N842 D855 N143 D156 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1102 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxp F 2.16 BS03 JBJ F 1 A743 I744 K745 E758 I759 M766 R776 L777 L788 M790 D855 F856 L858 L861 A44 I45 K46 E59 I60 M67 R77 L78 L89 M91 D156 F157 L159 L162 2.7.10.1 0004672,0004713,0005524,0006468 IC50=>1000nM P00533 1103 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM