7jxm A 2.192 BS01 ANP A 1 G719 G721 V726 A743 M790 M793 C797 D837 R841 N842 L844 D855 G20 G22 V27 A44 M87 M90 C94 D134 R138 N139 L141 D152 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERPSPTDSNFYRALMDEEDM 7jxm A 2.192 BS02 MG A 1 N842 D855 N139 D152 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1102 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERPSPTDSNFYRALMDEEDM 7jxm B 2.192 BS01 YY3 B 1 L718 G719 V726 A743 M793 G796 C797 D800 L18 G19 V26 A43 M93 G96 C97 D100 2.7.10.1 0004672,0004713,0005524,0006468 IC50=2.0nM, Ki=14nM, EC50=6.0nM P00533 1101 QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVD 7jxm B 2.192 BS02 9LL B 1 V726 A743 K745 I759 C775 R776 L777 L788 M790 D855 F856 L858 V26 A43 K45 I59 C75 R76 L77 L88 M90 D155 F156 L158 2.7.10.1 0004672,0004713,0005524,0006468 IC50=3.0nM P00533 1102 QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVD 7jxm C 2.192 BS01 ANP C 1 G719 S720 G721 A722 V726 A743 K745 M790 M793 C797 D837 R841 N842 L844 D855 G18 S19 G20 A21 V25 A42 K44 M84 M87 C91 D131 R135 N136 L138 D149 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1101 ALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEED 7jxm C 2.192 BS02 MG C 1 N842 D855 N136 D149 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1102 ALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEED 7jxm D 2.192 BS01 ANP D 1 S720 G721 A722 V726 A743 K745 M790 M793 C797 D837 R841 N842 L844 D855 S21 G22 A23 V27 A44 K46 M91 M94 C98 D138 R142 N143 L145 D156 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxm D 2.192 BS02 MG D 1 N842 D855 N143 D156 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1102 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM 7jxm D 2.192 BS03 9LL D 1 V726 A743 I744 K745 I759 C775 R776 L777 L788 M790 D855 F856 L858 V27 A44 I45 K46 I60 C76 R77 L78 L89 M91 D156 F157 L159 2.7.10.1 0004672,0004713,0005524,0006468 IC50=3.0nM P00533 1103 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM