6y81 A 1.54 BS01 SB4 A 1 V38 A51 K53 L104 V105 T106 M109 L167 V33 A46 K48 L99 V100 T101 M104 L162 D150 K152 N155 D168 T185 D145 K147 N150 D163 T170 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 32543856 401 PTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDSELKILDFGLYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEME 6y81 A 1.54 BS02 CA A 1 D354 E356 D339 E341 D150 K152 N155 D168 T185 D145 K147 N150 D163 T170 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 32543856 402 PTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDSELKILDFGLYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEME 6y81 A 1.54 BS03 CA A 2 D313 E359 D298 E344 D150 K152 N155 D168 T185 D145 K147 N150 D163 T170 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 32543856 403 PTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDSELKILDFGLYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEME 6y81 A 1.54 BS04 CA A 3 M268 N269 N272 M253 N254 N257 D150 K152 N155 D168 T185 D145 K147 N150 D163 T170 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 32543856 407 PTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDSELKILDFGLYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEME 6y81 A 1.54 BS05 OG5 A 1 L217 T218 R220 L222 L234 R237 V273 F274 I275 A277 L202 T203 R205 L207 L219 R222 V258 F259 I260 A262 D150 K152 N155 D168 T185 D145 K147 N150 D163 T170 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 Kd=25.1uM Kd=25100nM P47811 32543856 412 PTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDSELKILDFGLYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEME