6y0f A 2.924 BS01 356 A 1 E203 E204 Y541 W623 S624 Y625 Y656 Y660 E167 E168 Y505 W587 S588 Y589 Y620 Y624 Y541 S624 Y625 D702 H734 Y505 S588 Y589 D666 H698 3.4.14.5,3.4.21.-,3.4.21.26 0001525,0002020,0004175,0004252,0005178,0005515,0005576,0005615,0005737,0005886,0005925,0006508,0006915,0007155,0008233,0008236,0008239,0009986,0010710,0010716,0016020,0030027,0031258,0032587,0042802,0042803,0042995,0043542,0045177,0045178,0051603,0051726,0051917,0060244,0070161,0097325,1900119,1902362,1903054,1905368 IC50=89nM Q12884 806 NTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFS 6y0f B 2.924 BS01 356 B 1 E203 E204 Y541 W623 S624 Y625 Y656 Y660 E165 E166 Y503 W585 S586 Y587 Y618 Y622 Y541 S624 Y625 D702 H734 Y503 S586 Y587 D664 H696 3.4.14.5,3.4.21.-,3.4.21.26 0001525,0002020,0004175,0004252,0005178,0005515,0005576,0005615,0005737,0005886,0005925,0006508,0006915,0007155,0008233,0008236,0008239,0009986,0010710,0010716,0016020,0030027,0031258,0032587,0042802,0042803,0042995,0043542,0045177,0045178,0051603,0051726,0051917,0060244,0070161,0097325,1900119,1902362,1903054,1905368 IC50=89nM Q12884 809 MRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFS 6y0f C 2.924 BS01 356 C 1 E203 E204 Y541 W621 W623 S624 Y625 Y656 Y660 E168 E169 Y506 W586 W588 S589 Y590 Y621 Y625 Y541 S624 Y625 D702 H734 Y506 S589 Y590 D667 H699 3.4.14.5,3.4.21.-,3.4.21.26 0001525,0002020,0004175,0004252,0005178,0005515,0005576,0005615,0005737,0005886,0005925,0006508,0006915,0007155,0008233,0008236,0008239,0009986,0010710,0010716,0016020,0030027,0031258,0032587,0042802,0042803,0042995,0043542,0045177,0045178,0051603,0051726,0051917,0060244,0070161,0097325,1900119,1902362,1903054,1905368 IC50=89nM Q12884 806 ENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFS 6y0f D 2.924 BS01 356 D 1 E203 E204 Y541 W623 S624 Y625 Y656 Y660 E166 E167 Y504 W586 S587 Y588 Y619 Y623 Y541 S624 Y625 D702 H734 Y504 S587 Y588 D665 H697 3.4.14.5,3.4.21.-,3.4.21.26 0001525,0002020,0004175,0004252,0005178,0005515,0005576,0005615,0005737,0005886,0005925,0006508,0006915,0007155,0008233,0008236,0008239,0009986,0010710,0010716,0016020,0030027,0031258,0032587,0042802,0042803,0042995,0043542,0045177,0045178,0051603,0051726,0051917,0060244,0070161,0097325,1900119,1902362,1903054,1905368 IC50=89nM Q12884 808 TMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFS