6wp5 A 2.17 BS01 MG A 1 E272 D296 E252 D275 R73 R120 K270 T328 R53 R100 K250 T307 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 P14618 33453989 606 AMADTFLEHMCRLDIDDPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 6wp5 A 2.17 BS02 OXL A 1 K270 E272 A293 G295 D296 T328 K250 E252 A272 G274 D275 T307 R73 R120 K270 T328 R53 R100 K250 T307 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 P14618 33453989 607 AMADTFLEHMCRLDIDDPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 6wp5 A 2.17 BS03 FBP A 1 T432 K433 S434 S437 S519 G520 T411 K412 S413 S416 S498 G499 R73 R120 K270 T328 R53 R100 K250 T307 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 Kd=1uM P14618 33453989 608 AMADTFLEHMCRLDIDDPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 6wp5 B 2.17 BS01 MG B 1 E272 D296 E251 D275 R73 R120 K270 T328 R53 R100 K249 T307 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 P14618 33453989 605 AMADTFLEHMCRLDIDDPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 6wp5 B 2.17 BS02 OXL B 1 K270 A293 G295 D296 T328 K249 A272 G274 D275 T307 R73 R120 K270 T328 R53 R100 K249 T307 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 P14618 33453989 606 AMADTFLEHMCRLDIDDPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 6wp5 B 2.17 BS03 FBP B 1 T432 S434 S437 S519 G520 T411 S413 S416 S498 G499 R73 R120 K270 T328 R53 R100 K249 T307 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 Kd=1uM P14618 33453989 607 AMADTFLEHMCRLDIDDPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 6wp5 C 2.17 BS01 MG C 1 E272 D296 E248 D272 R73 R120 K270 T328 R53 R100 K246 T304 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 P14618 33453989 604 AMADTFLEHMCRLDIDDPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 6wp5 C 2.17 BS02 OXL C 1 K270 E272 A293 G295 D296 T328 K246 E248 A269 G271 D272 T304 R73 R120 K270 T328 R53 R100 K246 T304 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 P14618 33453989 605 AMADTFLEHMCRLDIDDPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 6wp5 D 2.17 BS01 OXL D 1 K270 E272 A293 G295 D296 K151 E153 A174 G176 D177 R73 K270 T328 R53 K151 T209 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 P14618 33453989 602 AMADTFLEHMCRLDIDDPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEILPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGGFTNTMRVVPVP 6wp5 D 2.17 BS02 FBP D 1 T432 K433 S434 S437 T313 K314 S315 S318 R73 K270 T328 R53 K151 T209 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 Kd=1uM P14618 33453989 603 AMADTFLEHMCRLDIDDPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEILPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGGFTNTMRVVPVP