6vty A 1.78 BS01 RLA A 1 F171 G181 C184 H185 L187 F188 I263 R265 V532 M536 F17 G27 C30 H31 L33 F34 I109 R111 V343 M347 N274 F278 S345 N347 T348 K429 N458 N120 F124 S191 N193 T194 K240 N269 1.3.5.2 0004152,0005737,0006207,0016020,0016627 ic50=0.1uM Q08210 32248693 1001 ADPFESYNPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGRKH 6vty A 1.78 BS02 FMN A 1 A225 G226 K229 T249 N274 N342 K429 S477 G478 S505 G506 G507 Y528 S529 A71 G72 K75 T95 N120 N188 K240 S288 G289 S316 G317 G318 Y339 S340 N274 F278 S345 N347 T348 K429 N458 N120 F124 S191 N193 T194 K240 N269 1.3.5.2 0004152,0005737,0006207,0016020,0016627 Q08210 32248693 1002 ADPFESYNPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGRKH 6vty B 1.78 BS01 RLA B 1 Y168 L172 G181 C184 H185 L187 F188 I263 R265 V532 Y9 L13 G22 C25 H26 L28 F29 I104 R106 V338 N274 F278 S345 N347 T348 K429 N458 N115 F119 S186 N188 T189 K235 N264 1.3.5.2 0004152,0005737,0006207,0016020,0016627 ic50=0.1uM Q08210 32248693 1001 SYNPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGRKH 6vty B 1.78 BS02 FMN B 1 A225 G226 T249 N274 N342 K429 S477 G478 S505 G506 G507 Y528 S529 A66 G67 T90 N115 N183 K235 S283 G284 S311 G312 G313 Y334 S335 N274 F278 S345 N347 T348 K429 N458 N115 F119 S186 N188 T189 K235 N264 1.3.5.2 0004152,0005737,0006207,0016020,0016627 Q08210 32248693 1002 SYNPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGRKH 6vty C 1.78 BS01 RLA C 1 L172 G181 C184 H185 L187 F188 I263 R265 V532 L7 G16 C19 H20 L22 F23 I98 R100 V332 N274 F278 S345 N347 T348 K429 N458 N109 F113 S180 N182 T183 K229 N258 1.3.5.2 0004152,0005737,0006207,0016020,0016627 ic50=0.1uM Q08210 32248693 1001 FLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGRKH 6vty C 1.78 BS02 FMN C 1 A225 G226 K229 T249 N274 N342 K429 S477 G478 S505 G506 G507 Y528 S529 A60 G61 K64 T84 N109 N177 K229 S277 G278 S305 G306 G307 Y328 S329 N274 F278 S345 N347 T348 K429 N458 N109 F113 S180 N182 T183 K229 N258 1.3.5.2 0004152,0005737,0006207,0016020,0016627 Q08210 32248693 1002 FLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGRKH 6vty D 1.78 BS01 RLA D 1 L172 G181 C184 H185 L187 F188 F227 I263 R265 V532 M536 L10 G19 C22 H23 L25 F26 F65 I101 R103 V334 M338 N274 F278 S345 N347 T348 K429 N458 N112 F116 S183 N185 T186 K231 N260 1.3.5.2 0004152,0005737,0006207,0016020,0016627 ic50=0.1uM Q08210 32248693 1001 PEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGRKH 6vty D 1.78 BS02 FMN D 1 A225 G226 T249 N274 N342 K429 S477 G478 S505 G506 G507 Y528 S529 A63 G64 T87 N112 N180 K231 S279 G280 S307 G308 G309 Y330 S331 N274 F278 S345 N347 T348 K429 N458 N112 F116 S183 N185 T186 K231 N260 1.3.5.2 0004152,0005737,0006207,0016020,0016627 Q08210 32248693 1002 PEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGRKH