6tp6 A 2.338 BS01 NT5 A 1 A102 S103 I122 P123 Q126 Q179 Y311 I314 N318 H344 A78 S79 I98 P99 Q102 Q155 Y240 I243 N247 H273 ? 0004930,0007186,0007631,0016020,0016499 Ki=2.5nM, IC50=16nM O43613 31860301 401 AASEDEFLRYLWRDYLYPKQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSWW 6tp6 A 2.338 BS02 PGW A 1 S138 W145 A226 M233 A234 Q237 S114 W121 A194 M201 A202 Q205 ? 0004930,0007186,0007631,0016020,0016499 O43613 31860301 411 AASEDEFLRYLWRDYLYPKQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSWW 6tp6 A 2.338 BS03 PGW B 1 A174 V177 P178 A181 Y215 A150 V153 P154 A157 Y183 ? 0004930,0007186,0007631,0016020,0016499 O43613 31860301 409 AASEDEFLRYLWRDYLYPKQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSWW 6tp6 B 2.338 BS01 PGW A 1 A174 V177 Y215 A132 V135 Y173 ? 0004930,0007186,0007631,0016020,0016499 O43613 31860301 411 KQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSWWL 6tp6 B 2.338 BS02 NT5 B 1 A102 S103 I122 P123 Q126 V130 Q179 Y311 H344 Y348 A60 S61 I80 P81 Q84 V88 Q137 Y237 H270 Y274 ? 0004930,0007186,0007631,0016020,0016499 Ki=2.5nM, IC50=16nM O43613 31860301 401 KQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSWWL 6tp6 B 2.338 BS03 PGW B 1 L230 M233 A234 Q237 R240 R245 L188 M191 A192 Q195 R198 R203 ? 0004930,0007186,0007631,0016020,0016499 O43613 31860301 409 KQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSWWL