6qxg A 2.08 BS01 UFP A 1 R50 C195 Q214 R215 S216 G217 D218 N226 H256 Y258 R25 C170 Q189 R190 S191 G192 D193 N201 H231 Y233 E87 W109 Y135 C195 R215 D218 E62 W84 Y110 C170 R190 D193 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 Ki=1.1nM Ki=14nM P04818 30935102 401 PPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMA 6qxg A 2.08 BS02 UFP B 1 R175 R176 R150 R151 E87 W109 Y135 C195 R215 D218 E62 W84 Y110 C170 R190 D193 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 Ki=1.1nM Ki=14nM P04818 30935102 401 PPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMA 6qxg B 2.08 BS01 UFP A 1 R175 R176 R150 R151 E87 W109 Y135 C195 R215 D218 E62 W84 Y110 C170 R190 D193 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 Ki=1.1nM Ki=14nM P04818 30935102 401 PPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKME 6qxg B 2.08 BS02 UFP B 1 R50 C195 R215 S216 D218 N226 H256 Y258 R25 C170 R190 S191 D193 N201 H231 Y233 E87 W109 Y135 C195 R215 D218 E62 W84 Y110 C170 R190 D193 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 Ki=1.1nM Ki=14nM P04818 30935102 401 PPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKME 6qxg C 2.08 BS01 UFP C 1 R50 C195 H196 Q214 R215 S216 G217 D218 N226 H256 Y258 R25 C170 H171 Q189 R190 S191 G192 D193 N201 H231 Y233 E87 W109 Y135 C195 R215 D218 E62 W84 Y110 C170 R190 D193 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 Ki=1.1nM Ki=14nM P04818 30935102 401 PPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMA