6orr A 2.25 BS01 N37 A 1 Y11 Y20 Y25 G63 S64 T67 Y69 D85 Y86 S87 C141 D142 V143 T163 L164 A169 S201 Y204 S213 Y22 Y31 Y36 G74 S75 T78 Y80 D96 Y97 S98 C152 D153 V154 T174 L175 A180 S212 Y215 S224 2.1.1.1 0005737,0005829,0006769,0008112,0008168,0009410,0030760,0031100,0032259,0034356,0045722,0090312 Ki=500pM -logKd/Ki=9.30, Ki=0.5nM Ki=500nM P40261 31589440 301 HHSSGLVPRGSMESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKAAPAAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKL 6orr B 2.25 BS01 N37 B 1 Y20 Y25 S64 Y69 D85 Y86 S87 C141 D142 V143 T163 L164 A169 S201 Y204 Y242 Y16 Y21 S60 Y65 D81 Y82 S83 C137 D138 V139 T159 L160 A165 S197 Y200 Y238 2.1.1.1 0005737,0005829,0006769,0008112,0008168,0009410,0030760,0031100,0032259,0034356,0045722,0090312 Ki=500pM Ki=500nM P40261 31589440 301 FTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKAAPAAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLS 6orr C 2.25 BS01 N37 C 1 Y11 Y20 Y25 G63 S64 Y69 D85 Y86 S87 C141 D142 T163 L164 A169 A198 S201 Y204 Y22 Y31 Y36 G74 S75 Y80 D96 Y97 S98 C152 D153 T174 L175 A180 A209 S212 Y215 2.1.1.1 0005737,0005829,0006769,0008112,0008168,0009410,0030760,0031100,0032259,0034356,0045722,0090312 Ki=500pM Ki=500nM P40261 31589440 301 HHSSGLVPRGSMESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKAAPAAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSR 6orr D 2.25 BS01 N37 D 1 Y11 Y20 S64 Y69 D85 Y86 S87 N90 C141 D142 V143 T163 L164 C165 A169 S201 Y204 Y242 Y7 Y16 S60 Y65 D81 Y82 S83 N86 C137 D138 V139 T159 L160 C161 A165 S197 Y200 Y238 2.1.1.1 0005737,0005829,0006769,0008112,0008168,0009410,0030760,0031100,0032259,0034356,0045722,0090312 Ki=500pM Ki=500nM P40261 31589440 301 FTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKAAPAAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLS