6oex A 2.1 BS01 FAD A 1 I10 G11 G13 S14 G15 D35 V36 A46 A47 G50 T51 C52 G56 C57 K60 W126 G127 T160 R287 R290 G326 D327 M333 L334 T335 I7 G8 G10 S11 G12 D32 V33 A43 A44 G47 T48 C49 G53 C54 K57 W123 G124 T157 R284 R287 G323 D324 M330 L331 T332 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S11 L45 C49 C54 K57 G82 S83 F195 E199 I336 G456 H458 E463 E482 K483 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 Q389T8 31407832 501 AFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLP 6oex A 2.1 BS02 EPE A 1 P398 L399 T463 S464 E466 E467 S470 P395 L396 T460 S461 E463 E464 S467 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S11 L45 C49 C54 K57 G82 S83 F195 E199 I336 G456 H458 E463 E482 K483 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 Q389T8 31407832 502 AFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLP 6oex A 2.1 BS03 M9Y A 1 W21 S109 G112 M113 W18 S106 G109 M110 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S11 L45 C49 C54 K57 G82 S83 F195 E199 I336 G456 H458 E463 E482 K483 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 Ki=1.5uM Q389T8 31407832 503 AFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLP 6oex B 2.1 BS01 FAD B 1 I10 G11 G13 S14 G15 V34 D35 A46 A47 G50 T51 C52 G56 C57 K60 W126 G127 T160 F198 R287 R290 G326 D327 M333 L334 T335 I8 G9 G11 S12 G13 V32 D33 A44 A45 G48 T49 C50 G54 C55 K58 W124 G125 T158 F196 R285 R288 G324 D325 M331 L332 T333 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S12 L46 C50 C55 K58 G83 S84 F196 E200 I337 G457 H459 E464 E483 K484 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 Q389T8 31407832 501 KAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLPD 6oex B 2.1 BS02 EPE B 1 A141 W163 R290 D293 A139 W161 R288 D291 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S12 L46 C50 C55 K58 G83 S84 F196 E200 I337 G457 H459 E464 E483 K484 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 Q389T8 31407832 502 KAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLPD 6oex B 2.1 BS03 M9Y B 1 W21 S109 Y110 G112 M113 D116 W19 S107 Y108 G110 M111 D114 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S12 L46 C50 C55 K58 G83 S84 F196 E200 I337 G457 H459 E464 E483 K484 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 Ki=1.5uM Q389T8 31407832 505 KAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLPD