6n1s A 3.0 BS01 UMP A 1 R344 C489 Q509 R510 S511 D513 N521 H551 Y553 R244 C389 Q409 R410 S411 D413 N421 H451 Y453 L23 D31 E381 W403 Y429 C489 R510 D513 L21 D29 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q07422 30624926 701 KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPASRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKATYRPIFISKTFSDNGVPYDFVVLEKRRSSAAAIAPVLAWMDLIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 6n1s A 3.0 BS02 NDP A 1 V9 A10 I17 N21 G22 L23 W25 G80 R81 K82 T83 V102 S103 S104 S105 V151 G152 G153 A154 G155 L156 V182 V7 A8 I15 N19 G20 L21 W23 G51 R52 K53 T54 V73 S74 S75 S76 V122 G123 G124 A125 G126 L127 V153 L23 D31 E381 W403 Y429 C489 R510 D513 L21 D29 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q07422 30624926 702 KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPASRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKATYRPIFISKTFSDNGVPYDFVVLEKRRSSAAAIAPVLAWMDLIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 6n1s A 3.0 BS03 K9A A 1 V8 V9 A10 D31 F32 F35 M87 V6 V7 A8 D29 F30 F33 M58 L23 D31 E381 W403 Y429 C489 R510 D513 L21 D29 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 IC50=4.0nM Q07422 30624926 704 KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPASRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKATYRPIFISKTFSDNGVPYDFVVLEKRRSSAAAIAPVLAWMDLIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 6n1s A 3.0 BS04 UMP B 1 R469 R470 R369 R370 L23 D31 E381 W403 Y429 C489 R510 D513 L21 D29 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q07422 30624926 701 KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPASRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKATYRPIFISKTFSDNGVPYDFVVLEKRRSSAAAIAPVLAWMDLIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 6n1s B 3.0 BS01 UMP A 1 R469 R470 R369 R370 L23 D31 E381 W403 Y429 C489 R510 D513 L20 D28 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q07422 30624926 701 PVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTASRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKATYRPIFISKTFSDNGVPYDFVVLEKRRSSAAAIAPVLAWMDEELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 6n1s B 3.0 BS02 UMP B 1 R344 C489 Q509 R510 S511 D513 N521 H551 Y553 R244 C389 Q409 R410 S411 D413 N421 H451 Y453 L23 D31 E381 W403 Y429 C489 R510 D513 L20 D28 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q07422 30624926 701 PVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTASRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKATYRPIFISKTFSDNGVPYDFVVLEKRRSSAAAIAPVLAWMDEELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 6n1s B 3.0 BS03 NDP B 1 V9 A10 I17 N21 G22 G80 R81 K82 T83 V102 S103 S104 V151 G153 A154 G155 V6 A7 I14 N18 G19 G49 R50 K51 T52 V71 S72 S73 V120 G122 A123 G124 L23 D31 E381 W403 Y429 C489 R510 D513 L20 D28 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q07422 30624926 702 PVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTASRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKATYRPIFISKTFSDNGVPYDFVVLEKRRSSAAAIAPVLAWMDEELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 6n1s B 3.0 BS04 K9A B 1 V8 V9 H27 D31 F32 F35 M87 V5 V6 H24 D28 F29 F32 M56 L23 D31 E381 W403 Y429 C489 R510 D513 L20 D28 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 IC50=4.0nM Q07422 30624926 704 PVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTASRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKATYRPIFISKTFSDNGVPYDFVVLEKRRSSAAAIAPVLAWMDEELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV