6m4w A 3.11 BS01 GLC J 1 D-356 K-355 E-259 Y-215 W-140 D15 K16 E112 Y156 W231 5.2.1.8 0003755,0005515,0006974,0008643,0015144,0015768,0016020,0030288,0034219,0034289,0042597,0042956,0043190,0055052,0055085,0060326,1901982,1990060 P0AEX9,P62942 32747768 1 MKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNAAAMGVQVETISPGDGRTFPKRGQTCVVHYTGMLE 6m4w A 3.11 BS02 GLC J 2 W-308 D-305 E-217 P-216 Y-215 W-30 W63 D66 E154 P155 Y156 W341 5.2.1.8 0003755,0005515,0006974,0008643,0015144,0015768,0016020,0030288,0034219,0034289,0042597,0042956,0043190,0055052,0055085,0060326,1901982,1990060 P0AEX9,P62942 32747768 2 MKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNAAAMGVQVETISPGDGRTFPKRGQTCVVHYTGMLE 6m4w A 3.11 BS03 RAP F 1 A-197 K-195 A174 K176 5.2.1.8 0003755,0005515,0006974,0008643,0015144,0015768,0016020,0030288,0034219,0034289,0042597,0042956,0043190,0055052,0055085,0060326,1901982,1990060 P0AEX9,P62942 32747768 201 MKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNAAAMGVQVETISPGDGRTFPKRGQTCVVHYTGMLE 6m4w B 3.11 BS01 GLC K 1 D-356 K-355 E-259 Y-215 W-140 D13 K14 E110 Y154 W227 5.2.1.8 0003755,0005515,0006974,0008643,0015144,0015768,0016020,0030288,0034219,0034289,0042597,0042956,0043190,0055052,0055085,0060326,1901982,1990060 P0AEX9,P62942 32747768 1 IEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNAAAMGVQVETISPGDGRTFPKRGQTCVVHYTGMLE 6m4w B 3.11 BS02 GLC K 2 W-308 D-305 R-304 E-217 P-216 Y-215 W-30 W61 D64 R65 E152 P153 Y154 W337 5.2.1.8 0003755,0005515,0006974,0008643,0015144,0015768,0016020,0030288,0034219,0034289,0042597,0042956,0043190,0055052,0055085,0060326,1901982,1990060 P0AEX9,P62942 32747768 2 IEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNAAAMGVQVETISPGDGRTFPKRGQTCVVHYTGMLE 6m4w C 3.11 BS01 GLC L 1 D-356 K-355 E-259 E-217 Y-215 W-140 D14 K15 E111 E151 Y153 W228 5.2.1.8 0003755,0005515,0006974,0008643,0015144,0015768,0016020,0030288,0034219,0034289,0042597,0042956,0043190,0055052,0055085,0060326,1901982,1990060 P0AEX9,P62942 32747768 1 KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKSALMFNLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNAAAMGVQVETISPGDGRFPKRGQTCVVHYTGMLE 6m4w C 3.11 BS02 GLC L 2 W-308 D-305 R-304 E-217 P-216 Y-215 W-30 W62 D65 R66 E151 P152 Y153 W338 5.2.1.8 0003755,0005515,0006974,0008643,0015144,0015768,0016020,0030288,0034219,0034289,0042597,0042956,0043190,0055052,0055085,0060326,1901982,1990060 P0AEX9,P62942 32747768 2 KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKSALMFNLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNAAAMGVQVETISPGDGRFPKRGQTCVVHYTGMLE 6m4w D 3.11 BS01 RAP D 1 D38 F47 E55 V56 W60 Y83 I91 D5 F14 E22 V23 W27 Y50 I58 5.2.1.8 0003755 IC50=0.600000nM, EC50=30nM, Ki=0.20nM P62942 32747768 201 GKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE 6m4w E 3.11 BS01 RAP E 1 F37 D38 F47 E55 V56 I57 W60 Y83 F5 D6 F15 E23 V24 I25 W28 Y51 5.2.1.8 0003755 IC50=0.600000nM, EC50=30nM, Ki=0.20nM P62942 32747768 201 DGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE 6m4w F 3.11 BS01 RAP F 1 F37 D38 E55 V56 W60 Y83 I91 F5 D6 E23 V24 W28 Y51 I59 5.2.1.8 0003755 IC50=0.600000nM, EC50=30nM, Ki=0.20nM P62942 32747768 201 DGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE 6m4w G 3.11 BS01 RAP D 1 L2031 S2035 R2036 F2039 L2098 W2101 Y2105 F2108 L12 S16 R17 F20 L79 W82 Y86 F89 2.7.11.1 0044877 IC50=>10000nM, Kd=0.600000nM P42345 32747768 201 SILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRIS 6m4w H 3.11 BS01 RAP E 1 L2031 S2035 F2039 L2098 Y2105 F2108 L12 S16 F20 L79 Y86 F89 2.7.11.1 0044877 IC50=>10000nM, Kd=0.600000nM P42345 32747768 201 SILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRIS 6m4w I 3.11 BS01 RAP F 1 L2031 S2035 R2036 F2039 L2098 W2101 Y2105 F2108 L12 S16 R17 F20 L79 W82 Y86 F89 2.7.11.1 0044877 IC50=>10000nM, Kd=0.600000nM P42345 32747768 201 SILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRIS