6lon A 2.2 BS01 LLQ A 1 R183 L186 Q187 S305 W368 G461 C462 E464 R672 R163 L166 Q167 S285 W348 G441 C442 E444 R652 W368 G461 C462 G799 W348 G441 C442 G779 4.4.1.41 0003824,0005829,0016829,0046306 Kd=6.7uM E5Y7I4 32571930 901 NRQGRERVYKILDRIQFTVPHVDIERARYFTESMRQTEGELLTLRWAKALKNVAEKMTVYITPDQLLAGRVGQLGRYGILYPEIDGDFYIEVMKDLPNREKSPFQIDPAAAAILMEEIAPYWEGKTYHEHLNKVLPAEIRGVTYHDERGLKSKFVVSETSSYRSALQWVPDYEKAMKRGFIDIQNEAKAKLAGLDLTNSVDIWEKKPFLEAMIIVCDAIMIWAKRHAQLARDTAAATSDPVRKQELLRMADICEHVPAYPARNFREAVQCQWFVQMFSRIEQKASAIISNGRMDQYLYPYYKKDIEEGTLTSEEAKELLECMWVDMAQFIDLYINPTGNEFQEGYAHWEAVTVGGQTPEGEDATNELSYLFLESKREFPMTYPDLAVRIHSRTPDRFLYEIALTVQDGSGFPKLINDEEVVPLNAIKGCPINEALDYAISGCTETRMPNRDTYTSGCVYINFATALEMLMNNGRLHYYGDELIGLETGDPTRFQTWEEFYEAYKAQHINLLQKAFQQQHIVDRLRPQHFAAPLSSVLHNLCMKNMQDLHSEKIEGGVDYSYFEFLGYATVVDSLAAIKKLVFEEKRLTMREVLDAMNANFVGYEPIQEMLKNAPCYGNNDPYADSIAKDVDRFTQVEAEKSSRDRGIHVDVRYVPITSHVPFGKIIAATPNGRVAGFPLADGSSASHGADHNGPTAVLLSNYHSKNYGMINRASRLLNIKLSPKCVAGEQGAKKIMSIIRTWCDLKLWHLQFNIVNRDTLLAAQKDPNSYRNLIVRVAGYSAYFCDMSPDLQNDIIDRTEHADL 6lon B 2.2 BS01 LLQ B 1 R183 L186 Q187 S305 W368 C462 E464 R672 R163 L166 Q167 S285 W348 C442 E444 R652 W368 G461 C462 G799 W348 G441 C442 G779 4.4.1.41 0003824,0005829,0016829,0046306 Kd=6.7uM E5Y7I4 32571930 901 NRQGRERVYKILDRIQFTVPHVDIERARYFTESMRQTEGELLTLRWAKALKNVAEKMTVYITPDQLLAGRVGQLGRYGILYPEIDGDFYIEVMKDLPNREKSPFQIDPAAAAILMEEIAPYWEGKTYHEHLNKVLPAEIRGVTYHDERGLKSKFVVSETSSYRSALQWVPDYEKAMKRGFIDIQNEAKAKLAGLDLTNSVDIWEKKPFLEAMIIVCDAIMIWAKRHAQLARDTAAATSDPVRKQELLRMADICEHVPAYPARNFREAVQCQWFVQMFSRIEQKASAIISNGRMDQYLYPYYKKDIEEGTLTSEEAKELLECMWVDMAQFIDLYINPTGNEFQEGYAHWEAVTVGGQTPEGEDATNELSYLFLESKREFPMTYPDLAVRIHSRTPDRFLYEIALTVQDGSGFPKLINDEEVVPLNAIKGCPINEALDYAISGCTETRMPNRDTYTSGCVYINFATALEMLMNNGRLHYYGDELIGLETGDPTRFQTWEEFYEAYKAQHINLLQKAFQQQHIVDRLRPQHFAAPLSSVLHNLCMKNMQDLHSEKIEGGVDYSYFEFLGYATVVDSLAAIKKLVFEEKRLTMREVLDAMNANFVGYEPIQEMLKNAPCYGNNDPYADSIAKDVDRFTQVEAEKSSRDRGIHVDVRYVPITSHVPFGKIIAATPNGRVAGFPLADGSSASHGADHNGPTAVLLSNYHSKNYGMINRASRLLNIKLSPKCVAGEQGAKKIMSIIRTWCDLKLWHLQFNIVNRDTLLAAQKDPNSYRNLIVRVAGYSAYFCDMSPDLQNDIIDRTEHA 6lon C 2.2 BS01 LLQ C 1 R183 L186 Q187 S305 W368 C462 E464 R672 R163 L166 Q167 S285 W348 C442 E444 R652 W368 G461 C462 G799 W348 G441 C442 G779 4.4.1.41 0003824,0005829,0016829,0046306 Kd=6.7uM E5Y7I4 32571930 901 NRQGRERVYKILDRIQFTVPHVDIERARYFTESMRQTEGELLTLRWAKALKNVAEKMTVYITPDQLLAGRVGQLGRYGILYPEIDGDFYIEVMKDLPNREKSPFQIDPAAAAILMEEIAPYWEGKTYHEHLNKVLPAEIRGVTYHDERGLKSKFVVSETSSYRSALQWVPDYEKAMKRGFIDIQNEAKAKLAGLDLTNSVDIWEKKPFLEAMIIVCDAIMIWAKRHAQLARDTAAATSDPVRKQELLRMADICEHVPAYPARNFREAVQCQWFVQMFSRIEQKASAIISNGRMDQYLYPYYKKDIEEGTLTSEEAKELLECMWVDMAQFIDLYINPTGNEFQEGYAHWEAVTVGGQTPEGEDATNELSYLFLESKREFPMTYPDLAVRIHSRTPDRFLYEIALTVQDGSGFPKLINDEEVVPLNAIKGCPINEALDYAISGCTETRMPNRDTYTSGCVYINFATALEMLMNNGRLHYYGDELIGLETGDPTRFQTWEEFYEAYKAQHINLLQKAFQQQHIVDRLRPQHFAAPLSSVLHNLCMKNMQDLHSEKIEGGVDYSYFEFLGYATVVDSLAAIKKLVFEEKRLTMREVLDAMNANFVGYEPIQEMLKNAPCYGNNDPYADSIAKDVDRFTQVEAEKSSRDRGIHVDVRYVPITSHVPFGKIIAATPNGRVAGFPLADGSSASHGADHNGPTAVLLSNYHSKNYGMINRASRLLNIKLSPKCVAGEQGAKKIMSIIRTWCDLKLWHLQFNIVNRDTLLAAQKDPNSYRNLIVRVAGYSAYFCDMSPDLQNDIIDRTEHADL 6lon D 2.2 BS01 LLQ D 1 R183 L186 Q187 S305 W368 C462 E464 R672 R163 L166 Q167 S285 W348 C442 E444 R652 W368 G461 C462 G799 W348 G441 C442 G779 4.4.1.41 0003824,0005829,0016829,0046306 Kd=6.7uM E5Y7I4 32571930 901 NRQGRERVYKILDRIQFTVPHVDIERARYFTESMRQTEGELLTLRWAKALKNVAEKMTVYITPDQLLAGRVGQLGRYGILYPEIDGDFYIEVMKDLPNREKSPFQIDPAAAAILMEEIAPYWEGKTYHEHLNKVLPAEIRGVTYHDERGLKSKFVVSETSSYRSALQWVPDYEKAMKRGFIDIQNEAKAKLAGLDLTNSVDIWEKKPFLEAMIIVCDAIMIWAKRHAQLARDTAAATSDPVRKQELLRMADICEHVPAYPARNFREAVQCQWFVQMFSRIEQKASAIISNGRMDQYLYPYYKKDIEEGTLTSEEAKELLECMWVDMAQFIDLYINPTGNEFQEGYAHWEAVTVGGQTPEGEDATNELSYLFLESKREFPMTYPDLAVRIHSRTPDRFLYEIALTVQDGSGFPKLINDEEVVPLNAIKGCPINEALDYAISGCTETRMPNRDTYTSGCVYINFATALEMLMNNGRLHYYGDELIGLETGDPTRFQTWEEFYEAYKAQHINLLQKAFQQQHIVDRLRPQHFAAPLSSVLHNLCMKNMQDLHSEKIEGGVDYSYFEFLGYATVVDSLAAIKKLVFEEKRLTMREVLDAMNANFVGYEPIQEMLKNAPCYGNNDPYADSIAKDVDRFTQVEAEKSSRDRGIHVDVRYVPITSHVPFGKIIAATPNGRVAGFPLADGSSASHGADHNGPTAVLLSNYHSKNYGMINRASRLLNIKLSPKCVAGEQGAKKIMSIIRTWCDLKLWHLQFNIVNRDTLLAAQKDPNSYRNLIVRVAGYSAYFCDMSPDLQNDIIDRTEHADL