6ilz A 3.261 BS01 AFU A 1 I260 Y334 T395 D396 F552 D553 I7 Y78 T139 D140 F285 D286 D378 K380 N383 D396 T416 D122 K124 N127 D140 T160 2.7.11.13 0004672,0004674,0005524,0006468,0007163 -logKd/Ki=6.47, IC50=0.34uM IC50=340nM P41743 30891133 601 FDLLRVIGRGSYAKVLLVRLDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 6ilz C 3.261 BS01 AFU C 1 I260 V268 E333 Y334 V335 T395 D396 F552 I7 V15 E77 Y78 V79 T139 D140 F284 D378 K380 N383 D396 T416 D122 K124 N127 D140 T160 2.7.11.13 0004672,0004674,0005524,0006468,0007163 IC50=340nM P41743 30891133 601 FDLLRVIGRGSYAKVLLVRLDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 6ilz E 3.261 BS01 AFU E 1 I260 V268 E333 Y334 V335 L385 T395 D396 I6 V14 E76 Y77 V78 L128 T138 D139 D378 K380 N383 D396 T416 D121 K123 N126 D139 T159 2.7.11.13 0004672,0004674,0005524,0006468,0007163 IC50=340nM P41743 30891133 601 DLLRVIGRGSYAKVLLVRLDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFEPVQLTPDDDDIVRKIDQSEFEGFEYINP 6ilz G 3.261 BS01 AFU G 1 I260 V268 I332 Y334 T395 D396 F552 I7 V15 I76 Y78 T139 D140 F282 D378 K380 N383 D396 T416 D122 K124 N127 D140 T160 2.7.11.13 0004672,0004674,0005524,0006468,0007163 IC50=340nM P41743 30891133 601 FDLLRVIGRGSYAKVLLVRLDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNIFGLDNFDSQFEPVQLTPDDDDIVRKIDQSEFEGFEYINP