6htd G 3.0 BS01 MG G 1 T8 R122 A123 M125 T7 R121 A122 M124 3.4.25.1 0000502,0003674,0005515,0005634,0005737,0005739,0005839,0006511,0010499,0019773,0043161,0051603 P21243 30657666 301 GYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTVVISQKKVPDKLLDPTTVSYIFCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYGYDMPCDVLAKRMANLSQIYTQRAYMRPLGVILTFVSVDEELGPSIYKTDPAGYYVGYKATATGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITHMIDALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAEQ 6htd H 3.0 BS01 GQH H 1 T1 T21 K33 G47 A49 D53 G128 S129 T1 T21 K33 G47 A49 D53 G128 S129 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=8.00, IC50=10nM Q99436 30657666 301 TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGGNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPL 6htd I 3.0 BS01 GQH H 1 D124 L125 D124 L125 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 -logKd/Ki=8.00, IC50=10nM P25451 30657666 301 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 6htd K 3.0 BS01 GQH K 1 T1 T21 V31 K33 M45 G47 A49 S131 T1 T21 V31 K33 M45 G47 A49 S131 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 30657666 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 6htd K 3.0 BS02 MG K 1 A165 D168 A169 A165 D168 A169 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 30657666 302 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 6htd V 3.0 BS01 GQH V 1 T1 T21 C31 K33 G47 A49 D53 G128 S129 T1 T21 C31 K33 G47 A49 D53 G128 S129 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 Q99436 30657666 301 TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGGNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPL 6htd V 3.0 BS02 MG V 1 I163 F164 D166 L167 I163 F164 D166 L167 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 Q99436 30657666 302 TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGGNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPL 6htd W 3.0 BS01 GQH V 1 D124 L125 D124 L125 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 P25451 30657666 301 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 6htd Y 3.0 BS01 GQH Y 1 T1 T21 V31 K33 M45 G47 A49 S131 T1 T21 V31 K33 M45 G47 A49 S131 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 30657666 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 6htd Y 3.0 BS02 MG Y 1 H166 D168 A169 H166 D168 A169 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 30657666 302 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG