6hoy A 1.7 BS01 AR6 A 1 G54 T57 D63 F64 R65 Q113 H133 G214 T215 S216 I219 N240 L241 Q242 Y257 V258 G45 T48 D54 F55 R56 Q104 H124 G198 T199 S200 I203 N224 L225 Q226 Y241 V242 P62 D63 F64 R65 N114 D116 H133 P53 D54 F55 R56 N105 D107 H124 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Q8N6T7 30395713 401 PFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKL 6hoy A 1.7 BS02 ZN A 1 C141 C144 C166 C177 C132 C135 C157 C161 P62 D63 F64 R65 N114 D116 H133 P53 D54 F55 R56 N105 D107 H124 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Q8N6T7 30395713 402 PFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKL 6hoy A 1.7 BS03 TSN A 1 A53 S56 F64 V70 W71 N114 D116 A44 S47 F55 V61 W62 N105 D107 P62 D63 F64 R65 N114 D116 H133 P53 D54 F55 R56 N105 D107 H124 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Kd=33uM -logKd/Ki=4.48, Kd=33uM Kd=33000nM, Ki=2000nM Q8N6T7 30395713 409 PFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKL 6hoy B 1.7 BS01 AR6 B 1 G52 G54 T57 D63 F64 R65 Q113 H133 G214 T215 S216 I219 N240 L241 Q242 Y257 V258 G38 G40 T43 D49 F50 R51 Q99 H119 G193 T194 S195 I198 N219 L220 Q221 Y236 V237 P62 D63 F64 R65 N114 D116 H133 P48 D49 F50 R51 N100 D102 H119 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Q8N6T7 30395713 702 KGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKL 6hoy B 1.7 BS02 ZN B 1 C141 C144 C166 C177 C127 C130 C152 C156 P62 D63 F64 R65 N114 D116 H133 P48 D49 F50 R51 N100 D102 H119 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Q8N6T7 30395713 703 KGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKL 6hoy B 1.7 BS03 TSN B 1 S56 F64 V70 W71 N114 V115 D116 S42 F50 V56 W57 N100 V101 D102 P62 D63 F64 R65 N114 D116 H133 P48 D49 F50 R51 N100 D102 H119 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Kd=33uM Kd=33000nM, Ki=2000nM Q8N6T7 30395713 709 KGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKL