6hk4 A 2.5 BS01 peptide N 0 H299 P300 W301 A315 S318 E322 H265 P266 W267 A281 S284 E288 D181 K183 N186 D200 S219 D147 K149 N152 D166 S185 2.7.11.1,2.7.11.26 0004672,0005524,0006468 P49841 31246463 419 ~ 427 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 6hk4 A 2.5 BS02 G8E A 1 I62 F67 A83 K85 D133 Y134 V135 R141 L188 D200 I28 F33 A49 K51 D99 Y100 V101 R107 L154 D166 D181 K183 N186 D200 S219 D147 K149 N152 D166 S185 2.7.11.1,2.7.11.26 0004672,0005524,0006468 Kd=2.81nM -logKd/Ki=8.55, Kd=2.81nM Ki=0.67nM P49841 31246463 408 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 6hk4 B 2.5 BS01 G8E B 1 I62 F67 V70 A83 K85 D133 Y134 V135 R141 L188 D200 I28 F33 V36 A49 K51 D99 Y100 V101 R107 L154 D166 D181 K183 N186 D200 S219 D147 K149 N152 D166 S185 2.7.11.1,2.7.11.26 0004672,0005524,0006468 Kd=2.81nM Ki=0.67nM P49841 31246463 409 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI