6h9b A 2.75 BS01 GTP A 1 G10 Q11 A12 Q15 A99 N101 S140 G143 G144 T145 G146 V177 T179 E183 N206 Y224 N228 G10 Q11 A12 Q15 A92 N94 S133 G136 G137 T138 G139 V170 T172 E176 N199 Y217 N221 ? 0000226,0000278,0000793,0001764,0001964,0005200,0005525,0005737,0005829,0005856,0005874,0005879,0005881,0005886,0006886,0007017,0007098,0007224,0007613,0007626,0008344,0008542,0009612,0010001,0010467,0015630,0016787,0021542,0021696,0021766,0021859,0021987,0022008,0030182,0030317,0030534,0031594,0034612,0035641,0036126,0036464,0042802,0044877,0045202,0046785,0046872,0046982,0048853,0048873,0050807,0050808,0051402,0055037,0061744,0071277,0072384,0140058,1902065 D0VWZ0 30525602 503 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVD 6h9b A 2.75 BS02 FWH B 1 A180 V181 A173 V174 ? 0000226,0000278,0000793,0001764,0001964,0005200,0005525,0005737,0005829,0005856,0005874,0005879,0005881,0005886,0006886,0007017,0007098,0007224,0007613,0007626,0008344,0008542,0009612,0010001,0010467,0015630,0016787,0021542,0021696,0021766,0021859,0021987,0022008,0030182,0030317,0030534,0031594,0034612,0035641,0036126,0036464,0042802,0044877,0045202,0046785,0046872,0046982,0048853,0048873,0050807,0050808,0051402,0055037,0061744,0071277,0072384,0140058,1902065 -logKd/Ki=5.70, IC50=2.0uM D0VWZ0 30525602 505 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVD 6h9b B 2.75 BS01 GDP B 1 G10 Q11 C12 S140 G143 G144 T145 G146 E183 N206 Y224 N228 G10 Q11 C12 S138 G141 G142 T143 G144 E181 N204 Y222 N226 ? 0000226,0000278,0003924,0005200,0005525,0005737,0005856,0005874,0007017,0046872 D0VWY9 30525602 504 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVATIFRGRMSMKEVDEQMLNIQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAD 6h9b B 2.75 BS02 FWH B 1 C241 A250 L255 N258 M259 A316 T317 N349 N350 K352 A354 C239 A248 L253 N256 M257 A314 T315 N347 N348 K350 A352 ? 0000226,0000278,0003924,0005200,0005525,0005737,0005856,0005874,0007017,0046872 -logKd/Ki=5.70, IC50=2.0uM D0VWY9 30525602 505 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVATIFRGRMSMKEVDEQMLNIQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAD 6h9b C 2.75 BS01 GTP C 1 Q11 A12 Q15 N101 S140 G143 G144 T145 G146 V177 T179 E183 N206 Y224 N228 Q11 A12 Q15 N94 S133 G136 G137 T138 G139 V170 T172 E176 N199 Y217 N221 ? 0000226,0000278,0000793,0001764,0001964,0005200,0005525,0005737,0005829,0005856,0005874,0005879,0005881,0005886,0006886,0007017,0007098,0007224,0007613,0007626,0008344,0008542,0009612,0010001,0010467,0015630,0016787,0021542,0021696,0021766,0021859,0021987,0022008,0030182,0030317,0030534,0031594,0034612,0035641,0036126,0036464,0042802,0044877,0045202,0046785,0046872,0046982,0048853,0048873,0050807,0050808,0051402,0055037,0061744,0071277,0072384,0140058,1902065 D0VWZ0 30525602 502 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSV 6h9b C 2.75 BS02 FWH D 1 T179 A180 V181 T172 A173 V174 ? 0000226,0000278,0000793,0001764,0001964,0005200,0005525,0005737,0005829,0005856,0005874,0005879,0005881,0005886,0006886,0007017,0007098,0007224,0007613,0007626,0008344,0008542,0009612,0010001,0010467,0015630,0016787,0021542,0021696,0021766,0021859,0021987,0022008,0030182,0030317,0030534,0031594,0034612,0035641,0036126,0036464,0042802,0044877,0045202,0046785,0046872,0046982,0048853,0048873,0050807,0050808,0051402,0055037,0061744,0071277,0072384,0140058,1902065 D0VWZ0 30525602 505 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSV 6h9b D 2.75 BS01 GDP D 1 G10 Q11 C12 Q15 S140 G143 G144 T145 G146 E183 N206 Y224 N228 G10 Q11 C12 Q15 S138 G141 G142 T143 G144 E181 N204 Y222 N226 ? 0000226,0000278,0003924,0005200,0005525,0005737,0005856,0005874,0007017,0046872 D0VWY9 30525602 504 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQLTVPELTQQMFDSKNMMAACDPRHGRYLTVATIFRGRMSMKEVDEQMLNIQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAD 6h9b D 2.75 BS02 FWH D 1 C241 A250 L255 N258 M259 A316 T317 I318 N349 N350 K352 A354 C239 A248 L253 N256 M257 A310 T311 I312 N343 N344 K346 A348 ? 0000226,0000278,0003924,0005200,0005525,0005737,0005856,0005874,0007017,0046872 D0VWY9 30525602 505 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQLTVPELTQQMFDSKNMMAACDPRHGRYLTVATIFRGRMSMKEVDEQMLNIQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAD