6h4y A 2.38 BS01 ZN A 1 H188 E190 H276 H173 E175 H261 G170 Y177 H188 E190 H276 S288 G155 Y162 H173 E175 H261 S273 1.14.11.66,1.14.11.69 O75164 31158747 401 LNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEF 6h4y A 2.38 BS02 ZN A 2 C234 H240 C306 C219 H225 C291 G170 Y177 H188 E190 H276 S288 G155 Y162 H173 E175 H261 S273 1.14.11.66,1.14.11.69 O75164 31158747 402 LNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEF 6h4y A 2.38 BS03 FO8 A 1 Y132 Y177 F185 H188 E190 K206 W208 K241 H276 Y125 Y162 F170 H173 E175 K191 W193 K226 H261 G170 Y177 H188 E190 H276 S288 G155 Y162 H173 E175 H261 S273 1.14.11.66,1.14.11.69 ic50=0.077uM -logKd/Ki=7.11, IC50=0.077uM IC50=77nM O75164 31158747 403 LNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEF 6h4y B 2.38 BS01 ZN B 1 H188 E190 H276 H175 E177 H263 G170 Y177 H188 E190 H276 S288 G157 Y164 H175 E177 H263 S275 1.14.11.66,1.14.11.69 O75164 31158747 401 ETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4y B 2.38 BS02 ZN B 2 C234 H240 C306 C221 H227 C293 G170 Y177 H188 E190 H276 S288 G157 Y164 H175 E177 H263 S275 1.14.11.66,1.14.11.69 O75164 31158747 402 ETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4y B 2.38 BS03 FO8 B 1 Y132 Y175 Y177 F185 H188 E190 K206 W208 H276 Y127 Y162 Y164 F172 H175 E177 K193 W195 H263 G170 Y177 H188 E190 H276 S288 G157 Y164 H175 E177 H263 S275 1.14.11.66,1.14.11.69 ic50=0.077uM IC50=77nM O75164 31158747 403 ETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4y C 2.38 BS01 ZN C 1 H188 E190 H276 H175 E177 H263 G170 Y177 H188 E190 H276 S288 G157 Y164 H175 E177 H263 S275 1.14.11.66,1.14.11.69 O75164 31158747 401 PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4y C 2.38 BS02 ZN C 2 C234 H240 C306 C221 H227 C293 G170 Y177 H188 E190 H276 S288 G157 Y164 H175 E177 H263 S275 1.14.11.66,1.14.11.69 O75164 31158747 402 PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4y C 2.38 BS03 FO8 C 1 Y132 Y177 F185 H188 E190 K206 W208 K241 H276 Y123 Y164 F172 H175 E177 K193 W195 K228 H263 G170 Y177 H188 E190 H276 S288 G157 Y164 H175 E177 H263 S275 1.14.11.66,1.14.11.69 ic50=0.077uM IC50=77nM O75164 31158747 403 PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4y D 2.38 BS01 ZN D 1 H188 E190 H276 H174 E176 H262 G170 Y177 H188 E190 H276 S288 G156 Y163 H174 E176 H262 S274 1.14.11.66,1.14.11.69 O75164 31158747 401 PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4y D 2.38 BS02 ZN D 2 C234 H240 C306 C308 C220 H226 C292 C294 G170 Y177 H188 E190 H276 S288 G156 Y163 H174 E176 H262 S274 1.14.11.66,1.14.11.69 O75164 31158747 402 PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4y D 2.38 BS03 FO8 D 1 Y132 Y175 Y177 F185 H188 E190 K206 W208 K241 H276 Y123 Y161 Y163 F171 H174 E176 K192 W194 K227 H262 G170 Y177 H188 E190 H276 S288 G156 Y163 H174 E176 H262 S274 1.14.11.66,1.14.11.69 ic50=0.077uM IC50=77nM O75164 31158747 403 PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL