6h4t A 2.38 BS01 ZN A 1 H188 E190 H276 H174 E176 H262 G170 Y177 H188 E190 H276 S288 G156 Y163 H174 E176 H262 S274 1.14.11.66,1.14.11.69 O75164 31158747 401 TLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4t A 2.38 BS02 ZN A 2 C234 H240 C306 C220 H226 C292 G170 Y177 H188 E190 H276 S288 G156 Y163 H174 E176 H262 S274 1.14.11.66,1.14.11.69 O75164 31158747 402 TLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4t A 2.38 BS03 FOW A 1 Y132 D135 Y175 Y177 F185 H188 E190 K206 W208 K241 H276 D311 Y126 D129 Y161 Y163 F171 H174 E176 K192 W194 K227 H262 D297 G170 Y177 H188 E190 H276 S288 G156 Y163 H174 E176 H262 S274 1.14.11.66,1.14.11.69 Ki=0.004uM -logKd/Ki=7.00, IC50=0.100uM IC50=423nM, EC50=4700nM, Ki=4.0nM O75164 31158747 403 TLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4t B 2.38 BS01 ZN B 1 H188 E190 H276 H174 E176 H262 G170 Y177 H188 E190 H276 S288 G156 Y163 H174 E176 H262 S274 1.14.11.66,1.14.11.69 O75164 31158747 401 TLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4t B 2.38 BS02 ZN B 2 C234 H240 C306 C220 H226 C292 G170 Y177 H188 E190 H276 S288 G156 Y163 H174 E176 H262 S274 1.14.11.66,1.14.11.69 O75164 31158747 402 TLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4t B 2.38 BS03 FOW B 1 Y132 D135 Y175 Y177 F185 H188 E190 K206 W208 K241 H276 Y126 D129 Y161 Y163 F171 H174 E176 K192 W194 K227 H262 G170 Y177 H188 E190 H276 S288 G156 Y163 H174 E176 H262 S274 1.14.11.66,1.14.11.69 Ki=0.004uM IC50=423nM, EC50=4700nM, Ki=4.0nM O75164 31158747 403 TLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4t C 2.38 BS01 ZN C 1 H188 E190 H276 H175 E177 H263 G170 Y177 H188 E190 H276 S288 G157 Y164 H175 E177 H263 S275 1.14.11.66,1.14.11.69 O75164 31158747 401 PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4t C 2.38 BS02 ZN C 2 C234 H240 C306 C221 H227 C293 G170 Y177 H188 E190 H276 S288 G157 Y164 H175 E177 H263 S275 1.14.11.66,1.14.11.69 O75164 31158747 402 PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4t C 2.38 BS03 FOW C 1 Y132 Y177 F185 H188 E190 K206 W208 H276 Y123 Y164 F172 H175 E177 K193 W195 H263 G170 Y177 H188 E190 H276 S288 G157 Y164 H175 E177 H263 S275 1.14.11.66,1.14.11.69 Ki=0.004uM IC50=423nM, EC50=4700nM, Ki=4.0nM O75164 31158747 403 PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4t D 2.38 BS01 ZN D 1 H188 E190 H276 H178 E180 H266 G170 Y177 H188 E190 H276 S288 G160 Y167 H178 E180 H266 S278 1.14.11.66,1.14.11.69 O75164 31158747 401 SETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4t D 2.38 BS02 ZN D 2 C234 H240 C306 C224 H230 C296 G170 Y177 H188 E190 H276 S288 G160 Y167 H178 E180 H266 S278 1.14.11.66,1.14.11.69 O75164 31158747 402 SETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4t D 2.38 BS03 FOW D 1 Y132 D135 Y175 Y177 F185 H188 E190 K206 W208 K241 H276 Y128 D131 Y165 Y167 F175 H178 E180 K196 W198 K231 H266 G170 Y177 H188 E190 H276 S288 G160 Y167 H178 E180 H266 S278 1.14.11.66,1.14.11.69 Ki=0.004uM IC50=423nM, EC50=4700nM, Ki=4.0nM O75164 31158747 403 SETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL