6ghv A 2.1 BS01 EZ8 A 1 F313 E347 N349 G352 E354 E358 N365 D367 K368 F61 E95 N97 G100 E102 E106 N113 D115 K116 ? Kd=52uM -logKd/Ki=4.28, Kd=52.0uM Q9NNX6 31469191 1001 CHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv A 2.1 BS02 CA A 1 E347 N349 E354 N365 D366 E95 N97 E102 N113 D114 ? Q9NNX6 31469191 1002 CHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv A 2.1 BS03 CA A 2 D320 E324 N350 E354 D355 D68 E72 N98 E102 D103 ? Q9NNX6 31469191 1003 CHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv A 2.1 BS04 EZ8 B 1 Q264 G265 Q12 G13 ? Kd=52uM -logKd/Ki=4.28, Kd=52.0uM Q9NNX6 31469191 1001 CHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv A 2.1 BS05 EZ8 D 1 N272 R309 S310 N311 R312 F374 N20 R57 S58 N59 R60 F122 ? Kd=52uM -logKd/Ki=4.28, Kd=52.0uM Q9NNX6 31469191 502 CHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv B 2.1 BS01 EZ8 B 1 F313 E347 N349 V351 G352 E354 E358 N365 D367 K368 F61 E95 N97 V99 G100 E102 E106 N113 D115 K116 ? Kd=52uM Q9NNX6 31469191 1001 CHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv B 2.1 BS02 CA B 1 E347 N349 E354 N365 D366 E95 N97 E102 N113 D114 ? Q9NNX6 31469191 1002 CHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv B 2.1 BS03 CA B 2 D320 E324 N350 E354 D355 D68 E72 N98 E102 D103 ? Q9NNX6 31469191 1003 CHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv B 2.1 BS04 EZ8 C 1 R309 S310 N311 R312 T314 F374 R57 S58 N59 R60 T62 F122 ? Kd=52uM Q9NNX6 31469191 1001 CHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv B 2.1 BS05 EZ8 F 1 Q264 G265 Q12 G13 ? Kd=52uM Q9NNX6 31469191 502 CHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv C 2.1 BS01 EZ8 B 1 R309 S310 N311 R312 T314 F374 R58 S59 N60 R61 T63 F123 ? Kd=52uM Q9NNX6 31469191 1001 LCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv C 2.1 BS02 EZ8 C 1 F313 E347 N349 V351 G352 E354 E358 N365 D367 K368 F62 E96 N98 V100 G101 E103 E107 N114 D116 K117 ? Kd=52uM Q9NNX6 31469191 1001 LCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv C 2.1 BS03 CA C 1 E347 N349 E354 N365 D366 E96 N98 E103 N114 D115 ? Q9NNX6 31469191 1002 LCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv C 2.1 BS04 CA C 2 D320 E324 N350 E354 D355 D69 E73 N99 E103 D104 ? Q9NNX6 31469191 1003 LCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv C 2.1 BS05 EZ8 D 1 Q264 G265 Q13 G14 ? Kd=52uM Q9NNX6 31469191 502 LCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv D 2.1 BS01 EZ8 A 1 R309 S310 N311 R312 R58 S59 N60 R61 ? Kd=52uM Q9NNX6 31469191 1001 LCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv D 2.1 BS02 EZ8 D 1 F313 E347 N349 V351 G352 E354 E358 S360 N365 D367 K368 F62 E96 N98 V100 G101 E103 E107 S109 N114 D116 K117 ? Kd=52uM Q9NNX6 31469191 502 LCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv D 2.1 BS03 CA D 1 E347 N349 E354 N365 D366 E96 N98 E103 N114 D115 ? Q9NNX6 31469191 503 LCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv D 2.1 BS04 CA D 2 D320 E324 N350 E354 D355 D69 E73 N99 E103 D104 ? Q9NNX6 31469191 504 LCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv E 2.1 BS01 EZ8 C 1 Q264 G265 Q13 G14 ? Kd=52uM Q9NNX6 31469191 1001 LCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv E 2.1 BS02 EZ8 E 1 F313 E347 N349 V351 G352 E354 E358 N365 D367 F62 E96 N98 V100 G101 E103 E107 N114 D116 ? Kd=52uM Q9NNX6 31469191 503 LCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv E 2.1 BS03 CA E 1 E347 N349 E354 N365 D366 E96 N98 E103 N114 D115 ? Q9NNX6 31469191 504 LCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv E 2.1 BS04 CA E 2 D320 E324 N350 E354 D355 D69 E73 N99 E103 D104 ? Q9NNX6 31469191 505 LCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv E 2.1 BS05 EZ8 F 1 N272 R309 S310 N311 R312 F374 N21 R58 S59 N60 R61 F123 ? Kd=52uM Q9NNX6 31469191 502 LCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv F 2.1 BS01 EZ8 E 1 R309 S310 N311 R312 F374 R57 S58 N59 R60 F122 ? Kd=52uM Q9NNX6 31469191 503 CHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv F 2.1 BS02 EZ8 F 1 F313 E347 N349 V351 G352 E354 E358 N365 D367 K368 F61 E95 N97 V99 G100 E102 E106 N113 D115 K116 ? Kd=52uM Q9NNX6 31469191 502 CHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv F 2.1 BS03 CA F 1 E347 N349 E354 N365 D366 E95 N97 E102 N113 D114 ? Q9NNX6 31469191 503 CHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC 6ghv F 2.1 BS04 CA F 2 D320 E324 N350 E354 D355 D68 E72 N98 E102 D103 ? Q9NNX6 31469191 504 CHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASC