6g98 A 2.47 BS01 ZN A 1 H94 H96 H119 H76 H78 H101 H64 H94 H96 E106 H119 T199 H50 H76 H78 E88 H101 T182 4.2.1.1 0004089,0008270 Q16790 29928486 301 RVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP 6g98 A 2.47 BS02 ER5 A 1 R60 N62 H64 Q67 Q92 H94 H96 V121 V131 L198 T199 T200 R46 N48 H50 Q53 Q74 H76 H78 V103 V112 L181 T182 T183 H64 H94 H96 E106 H119 T199 H50 H76 H78 E88 H101 T182 4.2.1.1 0004089,0008270 Kd=0.16nM -logKd/Ki=6.15, Kd=710nM Q16790 29928486 302 RVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP 6g98 B 2.47 BS01 ZN B 1 H94 H96 H119 H78 H80 H103 H64 H94 H96 E106 H119 T199 H52 H78 H80 E90 H103 T184 4.2.1.1 0004089,0008270 Q16790 29928486 301 WPRVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP 6g98 B 2.47 BS02 ER5 B 1 R60 N62 H64 Q92 H94 H96 V121 L198 T199 T200 R48 N50 H52 Q76 H78 H80 V105 L183 T184 T185 H64 H94 H96 E106 H119 T199 H52 H78 H80 E90 H103 T184 4.2.1.1 0004089,0008270 Kd=0.16nM Q16790 29928486 302 WPRVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP 6g98 C 2.47 BS01 ZN C 1 H94 H96 H119 H74 H76 H99 H64 H94 H96 E106 H119 T199 H48 H74 H76 E86 H99 T180 4.2.1.1 0004089,0008270 Q16790 29928486 301 SPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP 6g98 C 2.47 BS02 ER5 C 1 R60 N62 H64 Q92 H94 H96 V121 V131 L198 T199 T200 R44 N46 H48 Q72 H74 H76 V101 V110 L179 T180 T181 H64 H94 H96 E106 H119 T199 H48 H74 H76 E86 H99 T180 4.2.1.1 0004089,0008270 Kd=0.16nM Q16790 29928486 302 SPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP 6g98 D 2.47 BS01 ZN D 1 H94 H96 H119 H74 H76 H99 H64 H94 H96 E106 H119 T199 H48 H74 H76 E86 H99 T180 4.2.1.1 0004089,0008270 Q16790 29928486 301 SPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP 6g98 D 2.47 BS02 ER5 D 1 R60 N62 H64 Q92 H94 H96 L198 T199 T200 R44 N46 H48 Q72 H74 H76 L179 T180 T181 H64 H94 H96 E106 H119 T199 H48 H74 H76 E86 H99 T180 4.2.1.1 0004089,0008270 Kd=0.16nM Q16790 29928486 302 SPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP