6enm A 1.59 BS01 LPW A 1 I180 A182 L214 T215 H218 E219 H222 H228 V235 P238 T239 Y240 I69 A71 L103 T104 H107 E108 H111 H117 V124 P127 T128 Y129 H218 E219 H222 H228 H107 E108 H111 H117 3.4.24.65 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=8.32, IC50=4.8nM IC50=4.8nM P39900 29727184 301 HYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 6enm A 1.59 BS02 ZN A 1 H218 H222 H228 H107 H111 H117 H218 E219 H222 H228 H107 E108 H111 H117 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 29727184 302 HYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 6enm A 1.59 BS03 ZN A 2 H168 D170 H183 H196 H57 D59 H72 H85 H218 E219 H222 H228 H107 E108 H111 H117 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 29727184 303 HYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 6enm A 1.59 BS04 CA A 1 D158 G190 G192 D194 D47 G79 G81 D83 H218 E219 H222 H228 H107 E108 H111 H117 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 29727184 304 HYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 6enm A 1.59 BS05 CA A 2 D124 E199 E201 D13 E88 E90 H218 E219 H222 H228 H107 E108 H111 H117 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 29727184 305 HYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 6enm A 1.59 BS06 CA A 3 D175 G176 G178 I180 D198 E201 D64 G65 G67 I69 D87 E90 H218 E219 H222 H228 H107 E108 H111 H117 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 29727184 306 HYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 6enm B 1.59 BS01 LPW B 1 I180 L214 T215 H218 E219 H222 H228 V235 P238 T239 Y240 I69 L103 T104 H107 E108 H111 H117 V124 P127 T128 Y129 H218 E219 H222 H228 H107 E108 H111 H117 3.4.24.65 0004222,0006508,0008237,0008270,0031012 IC50=4.8nM P39900 29727184 301 HYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 6enm B 1.59 BS02 ZN B 1 H218 H222 H228 H107 H111 H117 H218 E219 H222 H228 H107 E108 H111 H117 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 29727184 302 HYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 6enm B 1.59 BS03 ZN B 2 H168 D170 H183 H196 H57 D59 H72 H85 H218 E219 H222 H228 H107 E108 H111 H117 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 29727184 303 HYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 6enm B 1.59 BS04 CA B 1 D158 G190 G192 D194 D47 G79 G81 D83 H218 E219 H222 H228 H107 E108 H111 H117 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 29727184 304 HYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 6enm B 1.59 BS05 CA B 2 D124 E199 E201 D13 E88 E90 H218 E219 H222 H228 H107 E108 H111 H117 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 29727184 305 HYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 6enm B 1.59 BS06 CA B 3 D175 G176 G178 I180 D198 E201 D64 G65 G67 I69 D87 E90 H218 E219 H222 H228 H107 E108 H111 H117 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 29727184 306 HYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG