6eil A 2.465 BS01 B6B A 1 I165 G166 A186 K188 S242 L294 V306 D307 I32 G33 A53 K55 S109 L161 V173 D174 D287 K289 N292 D307 S324 D154 K156 N159 D174 S191 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 -logKd/Ki=5.55, Ki>2800nM Ki=>2800nM, IC50=>6000nM Q13627 30095246 501 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTEYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 6eil B 2.465 BS01 B6B B 1 I165 A186 K188 F238 S242 L294 V306 D307 I33 A54 K56 F106 S110 L162 V174 D175 D287 K289 N292 D307 S324 D155 K157 N160 D175 S192 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Ki=>2800nM, IC50=>6000nM Q13627 30095246 501 RKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 6eil D 2.465 BS01 B6B D 1 I165 F238 S242 L294 V306 D307 I32 F105 S109 L161 V173 D174 D287 K289 N292 D307 S324 D154 K156 N159 D174 S191 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Ki=>2800nM, IC50=>6000nM Q13627 30095246 501 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKYKPPGTRKLHNILGVETGGPGGGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF