6ed6 A 2.86 BS01 J0P A 1 I98 G101 F103 G104 V106 A119 K121 L123 M169 Y171 M172 L221 D232 I72 G75 F77 G78 V80 A93 K95 L97 M143 Y145 M146 L195 D206 D214 K216 N219 D232 T253 D188 K190 N193 D206 T227 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=7.43, IC50=0.037uM IC50=37nM O75116 30384606 501 QRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIETFPIPKAFVGNQLPFIGFTY 6ed6 B 2.86 BS01 J0P B 1 I98 G101 G104 V106 A119 K121 Y171 M172 L221 A231 D232 I71 G74 G77 V79 A92 K94 Y144 M145 L194 A204 D205 D214 K216 N219 D232 T253 D187 K189 N192 D205 T214 2.7.11.1 0004672,0004674,0005524,0006468 IC50=37nM O75116 30384606 501 RKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMGTPDYISPEVLKSYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIETFPIPKAFVGNQLPFIGFTYY