6e4u A 3.27 BS01 STU A 1 L22 G23 V24 G25 V30 A43 M93 E94 Y95 V96 G99 E100 E143 N144 L146 D157 L14 G15 V16 G17 V22 A35 M85 E86 Y87 V88 G91 E92 E135 N136 L138 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 P54645 30036059 601 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDPGSHTIEFFEMCANLIKILAQ 6e4u A 3.27 BS02 HU7 A 1 L18 K29 K31 I46 D88 L10 K21 K23 I38 D80 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 -logKd/Ki=7.87, Kd=13.6nM P54645 30036059 602 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDPGSHTIEFFEMCANLIKILAQ 6e4u B 3.27 BS01 HU7 A 1 R83 N110 N111 V113 R7 N34 N35 V37 ? P80386 30036059 602 ARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSQNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKAPPILPPHLLQVILNKSCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 6e4u C 3.27 BS01 AMP C 1 H150 T199 I203 A204 V224 S225 I311 S313 D316 H125 T166 I170 A171 V191 S192 I272 S274 D277 ? 0004672,0004679,0005515,0005524,0005634,0005737,0005829,0006633,0010628,0016208,0019887,0019901,0031588,0031669,0032991,0043531,0044877,0051170 P80385 30036059 401 SVYTTFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRVLKCYLHETLEAIINRLVEAEVHRLVVVDEHDVVKGIVSLSDILQALV 6e4u C 3.27 BS02 AMP C 2 R69 I239 S241 F243 R268 V275 L276 V296 H297 R298 R44 I206 S208 F210 R235 V236 L237 V257 H258 R259 ? 0004672,0004679,0005515,0005524,0005634,0005737,0005829,0006633,0010628,0016208,0019887,0019901,0031588,0031669,0032991,0043531,0044877,0051170 P80385 30036059 402 SVYTTFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRVLKCYLHETLEAIINRLVEAEVHRLVVVDEHDVVKGIVSLSDILQALV 6e4u C 3.27 BS03 ADP C 1 R69 M84 T86 T88 D89 Y120 P127 L128 V129 I149 H150 R151 R44 M59 T61 T63 D64 Y95 P102 L103 V104 I124 H125 R126 ? 0004672,0004679,0005515,0005524,0005634,0005737,0005829,0006633,0010628,0016208,0019887,0019901,0031588,0031669,0032991,0043531,0044877,0051170 P80385 30036059 403 SVYTTFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRVLKCYLHETLEAIINRLVEAEVHRLVVVDEHDVVKGIVSLSDILQALV