6d50 A 2.5 BS01 CA A 1 D176 D341 D367 D145 D310 D336 ? 0004553,0005975 A0A078SUX9 30301767 901 QRQTQTINDSWKFLKGECTAAADSAFDDSKWTSIHLPHTWNTDAYTEKDYYRGTGWYRRQLTLPQGWKEKQIILRLDAAGKSATIYINGKNVGEHAGGYTACSFNITPFLSFDTPNTLAVCVDNARQDIAPISGDFTFFGGIYRDVWLTAVPNQHFNLTNHGSDGLFISTPQVSEEQATLSIRGEVKNDAPEKATLELTHTIYRPDGTLLQTLKKNIQLKAGETYAFSNEATPVLKPELWTPETPRLYRVETTLRNRKTKTLLDQSNHYTAFRWFRFDGDEGFFLNGKPYKLRGICRHQDQKPIGPALTDEMHRRDFLLMKEMGANFIRISHYPQDDALLEMCDKLGMLAWEEIPIIDIVPNTPGYGDNCERNLREMIRQHYNHPSIITWGYMNEILLVTQRKYKTEAELKPVLERTLALANRLERVLKEEDSTRISTMAFHGSNSYNETGLSKITDIVGWNLYQGWYGGDLTGFEKFLAQQHQNHPTHPMIVSEYGAGSDKRLHSLHPRAFDFSIEYQQKYLEHYLPVLEDTPYICGGTHWNFIDFSSALRDESMPRINNKGLVYADRTPKDVYHYYQAAWRKDIPVLHIASRDWTDRAGVQQGNAPVYLPVKIYTNLSEVELFIDGISLGKQKTENYTATFEVPFSNRNPFLFAQGNYQGKTVQDGLRINFTPIPACLDANNLKGLELAVNVGSQCFFTSDESQLTWLPDQPYAAGSWGYIGGKEGTAQTEIQNTADGPLFQTLRNEIEGYRFDAPQGVYEIELLFTDIFRESTFGISINGEVVEESLSPCKESGYFRALRKKYYITNDKEYIDIRFHSTSGTCFLNGIKLRNIY 6d50 A 2.5 BS02 GCB A 1 D166 H363 N425 E426 N493 Y495 Y499 E526 W573 N591 K593 D135 H332 N394 E395 N462 Y464 Y468 E495 W542 N560 K562 ? 0004553,0005975 -logKd/Ki=5.05, Kd=9uM A0A078SUX9 30301767 903 QRQTQTINDSWKFLKGECTAAADSAFDDSKWTSIHLPHTWNTDAYTEKDYYRGTGWYRRQLTLPQGWKEKQIILRLDAAGKSATIYINGKNVGEHAGGYTACSFNITPFLSFDTPNTLAVCVDNARQDIAPISGDFTFFGGIYRDVWLTAVPNQHFNLTNHGSDGLFISTPQVSEEQATLSIRGEVKNDAPEKATLELTHTIYRPDGTLLQTLKKNIQLKAGETYAFSNEATPVLKPELWTPETPRLYRVETTLRNRKTKTLLDQSNHYTAFRWFRFDGDEGFFLNGKPYKLRGICRHQDQKPIGPALTDEMHRRDFLLMKEMGANFIRISHYPQDDALLEMCDKLGMLAWEEIPIIDIVPNTPGYGDNCERNLREMIRQHYNHPSIITWGYMNEILLVTQRKYKTEAELKPVLERTLALANRLERVLKEEDSTRISTMAFHGSNSYNETGLSKITDIVGWNLYQGWYGGDLTGFEKFLAQQHQNHPTHPMIVSEYGAGSDKRLHSLHPRAFDFSIEYQQKYLEHYLPVLEDTPYICGGTHWNFIDFSSALRDESMPRINNKGLVYADRTPKDVYHYYQAAWRKDIPVLHIASRDWTDRAGVQQGNAPVYLPVKIYTNLSEVELFIDGISLGKQKTENYTATFEVPFSNRNPFLFAQGNYQGKTVQDGLRINFTPIPACLDANNLKGLELAVNVGSQCFFTSDESQLTWLPDQPYAAGSWGYIGGKEGTAQTEIQNTADGPLFQTLRNEIEGYRFDAPQGVYEIELLFTDIFRESTFGISINGEVVEESLSPCKESGYFRALRKKYYITNDKEYIDIRFHSTSGTCFLNGIKLRNIY 6d50 B 2.5 BS01 CA B 1 D176 D341 D367 D145 D310 D336 ? 0004553,0005975 A0A078SUX9 30301767 901 QRQTQTINDSWKFLKGECTAAADSAFDDSKWTSIHLPHTWNTDAYTEKDYYRGTGWYRRQLTLPQGWKEKQIILRLDAAGKSATIYINGKNVGEHAGGYTACSFNITPFLSFDTPNTLAVCVDNARQDIAPISGDFTFFGGIYRDVWLTAVPNQHFNLTNHGSDGLFISTPQVSEEQATLSIRGEVKNDAPEKATLELTHTIYRPDGTLLQTLKKNIQLKAGETYAFSNEATPVLKPELWTPETPRLYRVETTLRNRKTKTLLDQSNHYTAFRWFRFDGDEGFFLNGKPYKLRGICRHQDQKPIGPALTDEMHRRDFLLMKEMGANFIRISHYPQDDALLEMCDKLGMLAWEEIPIIDIVPNTPGYGDNCERNLREMIRQHYNHPSIITWGYMNEILLVTQRKYKTEAELKPVLERTLALANRLERVLKEEDSTRISTMAFHGSNSYNETGLSKITDIVGWNLYQGWYGGDLTGFEKFLAQQHQNHPTHPMIVSEYGAGSDKRLHSLHPRAFDFSIEYQQKYLEHYLPVLEDTPYICGGTHWNFIDFSSALRDESMPRINNKGLVYADRTPKDVYHYYQAAWRKDIPVLHIASRDWTDRAGVQQGNAPVYLPVKIYTNLSEVELFIDGISLGKQKTENYTATFEVPFSNRNPFLFAQGNYQGKTVQDGLRINFTPIPACLDANNLKGLELAVNVGSQCFFTSDESQLTWLPDQPYAAGSWGYIGGKEGTAQTEIQNTADGPLFQTLRNEIEGYRFDAPQGVYEIELLFTDIFRRNRESTFGISINGEVVEESLSPCKESGYFRALRKKYYITNDKEYIDIRFHSTSGTCFLNGIKLRNIY 6d50 B 2.5 BS02 GCB B 1 D166 H363 E426 Y495 Y499 E526 W573 N591 K593 D135 H332 E395 Y464 Y468 E495 W542 N560 K562 ? 0004553,0005975 A0A078SUX9 30301767 903 QRQTQTINDSWKFLKGECTAAADSAFDDSKWTSIHLPHTWNTDAYTEKDYYRGTGWYRRQLTLPQGWKEKQIILRLDAAGKSATIYINGKNVGEHAGGYTACSFNITPFLSFDTPNTLAVCVDNARQDIAPISGDFTFFGGIYRDVWLTAVPNQHFNLTNHGSDGLFISTPQVSEEQATLSIRGEVKNDAPEKATLELTHTIYRPDGTLLQTLKKNIQLKAGETYAFSNEATPVLKPELWTPETPRLYRVETTLRNRKTKTLLDQSNHYTAFRWFRFDGDEGFFLNGKPYKLRGICRHQDQKPIGPALTDEMHRRDFLLMKEMGANFIRISHYPQDDALLEMCDKLGMLAWEEIPIIDIVPNTPGYGDNCERNLREMIRQHYNHPSIITWGYMNEILLVTQRKYKTEAELKPVLERTLALANRLERVLKEEDSTRISTMAFHGSNSYNETGLSKITDIVGWNLYQGWYGGDLTGFEKFLAQQHQNHPTHPMIVSEYGAGSDKRLHSLHPRAFDFSIEYQQKYLEHYLPVLEDTPYICGGTHWNFIDFSSALRDESMPRINNKGLVYADRTPKDVYHYYQAAWRKDIPVLHIASRDWTDRAGVQQGNAPVYLPVKIYTNLSEVELFIDGISLGKQKTENYTATFEVPFSNRNPFLFAQGNYQGKTVQDGLRINFTPIPACLDANNLKGLELAVNVGSQCFFTSDESQLTWLPDQPYAAGSWGYIGGKEGTAQTEIQNTADGPLFQTLRNEIEGYRFDAPQGVYEIELLFTDIFRRNRESTFGISINGEVVEESLSPCKESGYFRALRKKYYITNDKEYIDIRFHSTSGTCFLNGIKLRNIY