6cve A 2.2 BS01 CTP A 1 T11 G12 V13 G14 K15 T16 V17 E108 G111 G169 P197 G199 A200 A201 T12 G13 V14 G15 K16 T17 V18 E109 G112 G170 P198 G200 A201 A202 T11 G12 K15 T16 K37 T41 G54 E108 T12 G13 K16 T17 K38 T42 G55 E109 6.3.3.3 0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 -logKd/Ki=6.80, Kd=0.16uM P9WPQ5 301 GGTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG 6cve A 2.2 BS02 MG A 1 T16 D49 E108 T17 D50 E109 T11 G12 K15 T16 K37 T41 G54 E108 T12 G13 K16 T17 K38 T42 G55 E109 6.3.3.3 0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 P9WPQ5 302 GGTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG 6cve A 2.2 BS03 DSD B 1 T11 K37 T41 P71 A73 V115 T12 K38 T42 P72 A74 V116 T11 G12 K15 T16 K37 T41 G54 E108 T12 G13 K16 T17 K38 T42 G55 E109 6.3.3.3 0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 P9WPQ5 301 GGTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG 6cve B 2.2 BS01 DSD B 1 G144 L146 N147 G145 L147 N148 T11 G12 K15 T16 K37 T41 G54 E108 T12 G13 K16 T17 K38 T42 G55 E109 6.3.3.3 0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 P9WPQ5 301 GGTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLV 6cve C 2.2 BS01 CTP C 1 G12 V13 G14 K15 T16 V17 E108 G169 G199 A200 A201 G14 V15 G16 K17 T18 V19 E110 G171 G201 A202 A203 T11 G12 K15 T16 K37 T41 G54 E108 T13 G14 K17 T18 K39 T43 G56 E110 6.3.3.3 0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 P9WPQ5 301 HGGTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG 6cve C 2.2 BS02 MG C 1 T16 D49 E108 T18 D51 E110 T11 G12 K15 T16 K37 T41 G54 E108 T13 G14 K17 T18 K39 T43 G56 E110 6.3.3.3 0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 P9WPQ5 302 HGGTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG 6cve C 2.2 BS03 DSD C 1 T11 K37 T41 A110 V115 T13 K39 T43 A112 V117 T11 G12 K15 T16 K37 T41 G54 E108 T13 G14 K17 T18 K39 T43 G56 E110 6.3.3.3 0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 P9WPQ5 303 HGGTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG 6cve C 2.2 BS04 DSD C 2 L143 G144 L146 N147 L145 G146 L148 N149 T11 G12 K15 T16 K37 T41 G54 E108 T13 G14 K17 T18 K39 T43 G56 E110 6.3.3.3 0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 P9WPQ5 304 HGGTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG 6cve D 2.2 BS01 DSD C 1 L143 G144 L146 N147 L145 G146 L148 N149 T11 G12 K15 T16 K37 T41 G54 E108 T13 G14 K17 T18 K39 T43 G56 E110 6.3.3.3 0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 P9WPQ5 303 HGGTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLV 6cve D 2.2 BS02 DSD C 2 T11 T41 P71 M72 A73 A110 V115 T13 T43 P73 M74 A75 A112 V117 T11 G12 K15 T16 K37 T41 G54 E108 T13 G14 K17 T18 K39 T43 G56 E110 6.3.3.3 0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 P9WPQ5 304 HGGTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLV 6cve D 2.2 BS03 CTP D 1 G12 G14 K15 T16 V17 G169 S170 L196 P197 G199 A200 A201 G14 G16 K17 T18 V19 G171 S172 L198 P199 G201 A202 A203 T11 G12 K15 T16 K37 T41 G54 E108 T13 G14 K17 T18 K39 T43 G56 E110 6.3.3.3 0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 P9WPQ5 301 HGGTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLV 6cve D 2.2 BS04 MG D 1 T16 D49 E108 T18 D51 E110 T11 G12 K15 T16 K37 T41 G54 E108 T13 G14 K17 T18 K39 T43 G56 E110 6.3.3.3 0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 P9WPQ5 302 HGGTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLV