6chh A 2.3 BS01 F0P A 1 Y11 Y20 Y25 G63 S64 G65 T67 Y69 D85 Y86 C141 D142 V143 T163 L164 A169 S201 Y204 S213 Y242 Y20 Y29 Y34 G70 S71 G72 T74 Y76 D92 Y93 C148 D149 V150 T170 L171 A176 S208 Y211 S220 Y249 2.1.1.1 0005737,0005829,0006769,0008112,0008168,0009410,0030760,0031100,0032259,0034356,0045722,0090312 -logKd/Ki=5.57, Kd=2.7uM Ki=89nM, IC50=4360nM, Kd=2700nM P40261 29320176 301 SSGLVPRGSMESGFTSKDTYLSHFNPRDYLEKYYKSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKAAPAAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSR 6chh B 2.3 BS01 F0P B 1 Y11 Y20 Y25 G63 S64 T67 Y69 D85 Y86 N90 C141 D142 V143 T163 L164 C165 A169 S201 Y204 S213 Y242 Y20 Y29 Y34 G68 S69 T72 Y74 D90 Y91 N95 C146 D147 V148 T168 L169 C170 A174 S206 Y209 S218 Y247 2.1.1.1 0005737,0005829,0006769,0008112,0008168,0009410,0030760,0031100,0032259,0034356,0045722,0090312 Ki=89nM, IC50=4360nM, Kd=2700nM P40261 29320176 303 SSGLVPRGSMESGFTSKDTYLSHFNPRDYLEKYYKHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKAAPAAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSR 6chh C 2.3 BS01 F0P C 1 Y20 Y25 G63 S64 T67 Y69 D85 Y86 C141 D142 V143 T163 L164 C165 A169 S201 Y204 S213 Y242 Y5 Y10 G46 S47 T50 Y52 D68 Y69 C124 D125 V126 T146 L147 C148 A152 S184 Y187 S196 Y225 2.1.1.1 0005737,0005829,0006769,0008112,0008168,0009410,0030760,0031100,0032259,0034356,0045722,0090312 Ki=89nM, IC50=4360nM, Kd=2700nM P40261 29320176 301 NPRDYLEKYYKFGHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKAAPAAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLS 6chh D 2.3 BS01 F0P D 1 Y20 Y24 Y25 G63 S64 T67 Y69 D85 Y86 N90 C141 D142 V143 T163 L164 C165 A169 S201 Y204 S213 Y242 Y5 Y9 Y10 G45 S46 T49 Y51 D67 Y68 N72 C123 D124 V125 T145 L146 C147 A151 S183 Y186 S195 Y224 2.1.1.1 0005737,0005829,0006769,0008112,0008168,0009410,0030760,0031100,0032259,0034356,0045722,0090312 Ki=89nM, IC50=4360nM, Kd=2700nM P40261 29320176 301 NPRDYLEKYYKRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKAAPAAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLS