6c4d A 2.52 BS01 EJP A 1 K45 L70 V76 L78 L90 M92 V134 A155 D156 L157 L159 S161 F162 K31 L56 V62 L64 L76 M78 V120 A141 D142 L143 L145 S147 F148 D138 K140 E142 N143 D156 T189 D124 K126 E128 N129 D142 T162 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=9.04, Ki=0.912nM IC50=1.3nM, Ki=0.912011nM Q13546 29485864 1100 NVIKMKSSDFLEGFGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE 6c4d B 2.52 BS01 EJP B 1 V31 K45 M67 V76 L90 M92 A155 D156 L157 V19 K33 M55 V64 L78 M80 A143 D144 L145 D138 K140 E142 N143 D156 T189 D126 K128 E130 N131 D144 T161 2.7.11.1 0004672,0005524,0006468 IC50=1.3nM, Ki=0.912011nM Q13546 29485864 1100 LNVIKMKSSDFLESAELKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE 6c4d C 2.52 BS01 EJP C 1 K45 M67 L70 V76 L90 M92 V134 A155 D156 L157 F162 K31 M49 L52 V58 L72 M74 V116 A137 D138 L139 F144 D138 K140 E142 N143 D156 T189 D120 K122 E124 N125 D138 T153 2.7.11.1 0004672,0005524,0006468 IC50=1.3nM, Ki=0.912011nM Q13546 29485864 1100 IKMKSSDFLESAELDKVSLAFHRTQGLMIMKTVYKGPHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE 6c4d D 2.52 BS01 EJP D 1 V31 I43 K45 M67 V76 M92 A155 D156 L157 F162 V20 I32 K34 M56 V65 M81 A144 D145 L146 F151 D138 K140 E142 N143 D156 T189 D127 K129 E131 N132 D145 T162 2.7.11.1 0004672,0005524,0006468 IC50=1.3nM, Ki=0.912011nM Q13546 29485864 1100 MSLNVIKMKSSDFLESAGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQL