6b9p A 1.996 BS01 BMA C 1 A402 K403 Y520 A402 K403 Y515 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 3 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNGQPPPHTSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p A 1.996 BS02 MAN C 1 F374 K403 F374 K403 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 7 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNGQPPPHTSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p A 1.996 BS03 MAN C 2 V799 C800 V771 C772 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 9 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNGQPPPHTSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p A 1.996 BS04 MAN C 3 K518 M801 K513 M773 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 10 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNGQPPPHTSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p A 1.996 BS05 MAN C 4 Q34 H396 D400 K403 Q34 H396 D400 K403 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 12 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNGQPPPHTSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p A 1.996 BS06 MAN E 6 F234 D235 F234 D235 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 12 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNGQPPPHTSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p A 1.996 BS07 D0J A 1 H23 D25 W28 D145 D268 H386 D387 Y625 G788 R789 H23 D25 W28 D145 D268 H386 D387 Y600 G760 R761 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 Ki=0.001uM C0HJB3 29722924 1001 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNGQPPPHTSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p A 1.996 BS08 ZN A 1 H23 D25 D145 H386 H23 D25 D145 H386 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 1002 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNGQPPPHTSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p B 1.996 BS01 MAN C 4 F234 D235 F234 D235 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 12 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSSLTGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p B 1.996 BS02 BMA E 1 K403 Y520 K403 Y515 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 3 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSSLTGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p B 1.996 BS03 MAN E 1 A406 I407 A406 I407 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 5 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSSLTGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p B 1.996 BS04 MAN E 2 F374 K403 F374 K403 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 7 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSSLTGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p B 1.996 BS05 MAN E 3 V799 C800 V767 C768 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 9 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSSLTGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p B 1.996 BS06 MAN E 4 K518 G522 C800 K513 G517 C768 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 10 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSSLTGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p B 1.996 BS07 MAN E 5 H396 N399 H396 N399 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 11 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSSLTGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p B 1.996 BS08 MAN E 6 Q34 H396 D400 K403 Q34 H396 D400 K403 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 12 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSSLTGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p B 1.996 BS09 D0J B 1 H23 D25 W28 D145 D268 H386 D387 Y625 G788 R789 G790 H23 D25 W28 D145 D268 H386 D387 Y603 G756 R757 G758 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 Ki=0.001uM C0HJB3 29722924 1001 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSSLTGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF 6b9p B 1.996 BS10 ZN B 1 H23 D25 D145 H386 H23 D25 D145 H386 3.2.1.24 0000326,0003824,0004559,0005773,0005975,0006013,0016787,0016798,0030246,0046872 C0HJB3 29722924 1002 MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAALTQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYSTPSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTESSIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNIGPGDLKMSFSSLTGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASGAYIFRPNSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF