6b5g A 2.2 BS01 NAD A 1 I183 I184 P185 W186 N187 M192 K210 E213 G243 G247 F261 T262 G263 S264 V267 E286 L287 C320 E417 F419 I157 I158 P159 W160 N161 M166 K184 E187 G217 G221 F235 T236 G237 S238 V241 E260 L261 C294 E391 F393 N187 E286 C320 E494 N161 E260 C294 E468 1.2.1.36 0001568,0001758,0001822,0001889,0002138,0003007,0004028,0004029,0005737,0005829,0006629,0006776,0007494,0008283,0008284,0008285,0009855,0009952,0009954,0010628,0014032,0016331,0016491,0016620,0016918,0021915,0021983,0030182,0030324,0030326,0030900,0030902,0031016,0031076,0032355,0032526,0033189,0034097,0035115,0035799,0042572,0042573,0042574,0042904,0043010,0043065,0048384,0048471,0048566,0048738,0051289,0060324,0071300,1905562 O94788 29240402 601 PSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 6b5g A 2.2 BS02 CQY A 1 F188 L191 W195 F314 C319 C320 T321 N475 L477 F162 L165 W169 F288 C293 C294 T295 N449 L451 N187 E286 C320 E494 N161 E260 C294 E468 1.2.1.36 0001568,0001758,0001822,0001889,0002138,0003007,0004028,0004029,0005737,0005829,0006629,0006776,0007494,0008283,0008284,0008285,0009855,0009952,0009954,0010628,0014032,0016331,0016491,0016620,0016918,0021915,0021983,0030182,0030324,0030326,0030900,0030902,0031016,0031076,0032355,0032526,0033189,0034097,0035115,0035799,0042572,0042573,0042574,0042904,0043010,0043065,0048384,0048471,0048566,0048738,0051289,0060324,0071300,1905562 Kd=0.26uM O94788 29240402 602 PSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 6b5g B 2.2 BS01 NAD B 1 I183 I184 P185 W186 K210 G243 G247 A248 T262 G263 S264 V267 E286 L287 C320 E417 I157 I158 P159 W160 K184 G217 G221 A222 T236 G237 S238 V241 E260 L261 C294 E391 N187 E286 C320 E494 N161 E260 C294 E468 1.2.1.36 0001568,0001758,0001822,0001889,0002138,0003007,0004028,0004029,0005737,0005829,0006629,0006776,0007494,0008283,0008284,0008285,0009855,0009952,0009954,0010628,0014032,0016331,0016491,0016620,0016918,0021915,0021983,0030182,0030324,0030326,0030900,0030902,0031016,0031076,0032355,0032526,0033189,0034097,0035115,0035799,0042572,0042573,0042574,0042904,0043010,0043065,0048384,0048471,0048566,0048738,0051289,0060324,0071300,1905562 O94788 29240402 601 PSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 6b5g B 2.2 BS02 CQY B 1 F188 L191 M192 W195 C319 C320 T321 N475 L477 F162 L165 M166 W169 C293 C294 T295 N449 L451 N187 E286 C320 E494 N161 E260 C294 E468 1.2.1.36 0001568,0001758,0001822,0001889,0002138,0003007,0004028,0004029,0005737,0005829,0006629,0006776,0007494,0008283,0008284,0008285,0009855,0009952,0009954,0010628,0014032,0016331,0016491,0016620,0016918,0021915,0021983,0030182,0030324,0030326,0030900,0030902,0031016,0031076,0032355,0032526,0033189,0034097,0035115,0035799,0042572,0042573,0042574,0042904,0043010,0043065,0048384,0048471,0048566,0048738,0051289,0060324,0071300,1905562 Kd=0.26uM O94788 29240402 602 PSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 6b5g C 2.2 BS01 NAD C 1 I183 I184 P185 W186 N187 M192 K210 G243 G247 F261 T262 G263 S264 V267 E286 L287 C320 E417 I157 I158 P159 W160 N161 M166 K184 G217 G221 F235 T236 G237 S238 V241 E260 L261 C294 E391 N187 E286 C320 E494 N161 E260 C294 E468 1.2.1.36 0001568,0001758,0001822,0001889,0002138,0003007,0004028,0004029,0005737,0005829,0006629,0006776,0007494,0008283,0008284,0008285,0009855,0009952,0009954,0010628,0014032,0016331,0016491,0016620,0016918,0021915,0021983,0030182,0030324,0030326,0030900,0030902,0031016,0031076,0032355,0032526,0033189,0034097,0035115,0035799,0042572,0042573,0042574,0042904,0043010,0043065,0048384,0048471,0048566,0048738,0051289,0060324,0071300,1905562 O94788 29240402 601 PSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 6b5g C 2.2 BS02 CQY C 1 F188 L191 W195 F314 C319 C320 T321 N475 L477 F162 L165 W169 F288 C293 C294 T295 N449 L451 N187 E286 C320 E494 N161 E260 C294 E468 1.2.1.36 0001568,0001758,0001822,0001889,0002138,0003007,0004028,0004029,0005737,0005829,0006629,0006776,0007494,0008283,0008284,0008285,0009855,0009952,0009954,0010628,0014032,0016331,0016491,0016620,0016918,0021915,0021983,0030182,0030324,0030326,0030900,0030902,0031016,0031076,0032355,0032526,0033189,0034097,0035115,0035799,0042572,0042573,0042574,0042904,0043010,0043065,0048384,0048471,0048566,0048738,0051289,0060324,0071300,1905562 Kd=0.26uM O94788 29240402 602 PSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 6b5g D 2.2 BS01 NAD D 1 I183 I184 P185 W186 N187 M192 K210 E213 G243 G247 A248 F261 T262 G263 S264 V267 E286 G288 C320 E417 F419 I157 I158 P159 W160 N161 M166 K184 E187 G217 G221 A222 F235 T236 G237 S238 V241 E260 G262 C294 E391 F393 N187 E286 C320 E494 N161 E260 C294 E468 1.2.1.36 0001568,0001758,0001822,0001889,0002138,0003007,0004028,0004029,0005737,0005829,0006629,0006776,0007494,0008283,0008284,0008285,0009855,0009952,0009954,0010628,0014032,0016331,0016491,0016620,0016918,0021915,0021983,0030182,0030324,0030326,0030900,0030902,0031016,0031076,0032355,0032526,0033189,0034097,0035115,0035799,0042572,0042573,0042574,0042904,0043010,0043065,0048384,0048471,0048566,0048738,0051289,0060324,0071300,1905562 O94788 29240402 601 PSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 6b5g D 2.2 BS02 CQY D 1 F188 L191 W195 F314 C319 C320 T321 N475 L477 F162 L165 W169 F288 C293 C294 T295 N449 L451 N187 E286 C320 E494 N161 E260 C294 E468 1.2.1.36 0001568,0001758,0001822,0001889,0002138,0003007,0004028,0004029,0005737,0005829,0006629,0006776,0007494,0008283,0008284,0008285,0009855,0009952,0009954,0010628,0014032,0016331,0016491,0016620,0016918,0021915,0021983,0030182,0030324,0030326,0030900,0030902,0031016,0031076,0032355,0032526,0033189,0034097,0035115,0035799,0042572,0042573,0042574,0042904,0043010,0043065,0048384,0048471,0048566,0048738,0051289,0060324,0071300,1905562 Kd=0.26uM O94788 29240402 602 PSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS