6ar9 A 2.28 BS01 3L4 A 1 G88 D148 D151 T152 G153 T155 K180 Y201 V202 E208 R214 G81 D128 D131 T132 G133 T135 K160 Y181 V182 E188 R194 E147 D148 D151 Y201 R214 E127 D128 D131 Y181 R194 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=6.54uM -logKd/Ki=5.18, Ki=6.54uM Q38CA1 29481567 301 KPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6ar9 A 2.28 BS02 MG A 1 E147 D148 E127 D128 E147 D148 D151 Y201 R214 E127 D128 D131 Y181 R194 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Q38CA1 29481567 303 KPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6ar9 B 2.28 BS01 3L4 B 1 G88 D148 A150 D151 T152 G153 T155 K180 Y201 V202 F207 E208 G81 D126 A128 D129 T130 G131 T133 K158 Y179 V180 F185 E186 E147 D148 D151 Y201 R214 E125 D126 D129 Y179 R192 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=6.54uM Q38CA1 29481567 301 KPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRILDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6ar9 C 2.28 BS01 3L4 C 1 G88 D148 D151 T152 G153 T155 K180 Y201 V202 F207 E208 G80 D123 D126 T127 G128 T130 K155 Y176 V177 F182 E183 E147 D148 D151 Y201 R214 E122 D123 D126 Y176 R189 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=6.54uM Q38CA1 29481567 301 PNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRINLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6ar9 D 2.28 BS01 3L4 D 1 I149 D151 T152 G153 T155 K180 Y201 V202 E208 I124 D126 T127 G128 T130 K155 Y176 V177 E183 E147 D148 D151 Y201 R214 E122 D123 D126 Y176 R189 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=6.54uM Q38CA1 29481567 301 PNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRINLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6ar9 D 2.28 BS02 MG D 1 G88 E208 R214 G80 E183 R189 E147 D148 D151 Y201 R214 E122 D123 D126 Y176 R189 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Q38CA1 29481567 303 PNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRINLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6ar9 E 2.28 BS01 3L4 E 1 I149 D151 T152 G153 T155 K180 Y201 V202 E208 I129 D131 T132 G133 T135 K160 Y181 V182 E188 E147 D148 D151 Y201 R214 E127 D128 D131 Y181 R194 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=6.54uM Q38CA1 29481567 301 PNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6ar9 E 2.28 BS02 MG E 1 V85 G88 S89 E147 D148 V77 G80 S81 E127 D128 E147 D148 D151 Y201 R214 E127 D128 D131 Y181 R194 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Q38CA1 29481567 303 PNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6ar9 F 2.28 BS01 3L4 F 1 I149 D151 T152 G153 T155 K180 Y201 V202 E208 I128 D130 T131 G132 T134 K159 Y180 V181 E187 E147 D148 D151 Y201 R214 E126 D127 D130 Y180 R193 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=6.54uM Q38CA1 29481567 301 KPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRIVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL