6alz A 2.208 BS01 MN A 1 D92 N124 H173 H248 D86 N118 H167 H242 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0016787 P62136 29156132 401 LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA 6alz A 2.208 BS02 MN A 2 D64 H66 D92 D58 H60 D86 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0016787 P62136 29156132 402 LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA 6alz A 2.208 BS03 BKM A 1 R96 C127 S129 Y134 V195 W206 R221 V223 V250 Y272 F276 R90 C121 S123 Y128 V189 W200 R215 V217 V244 Y266 F270 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0016787 -logKd/Ki=10.42, IC50=38pM P62136 29156132 403 LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA 6alz B 2.208 BS01 MN B 1 D64 H66 D92 D59 H61 D87 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D59 H61 D87 D90 R91 N119 H120 H168 R216 H243 3.1.3.16 0016787 P62136 29156132 401 SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA 6alz B 2.208 BS02 MN B 2 D92 N124 H173 H248 D87 N119 H168 H243 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D59 H61 D87 D90 R91 N119 H120 H168 R216 H243 3.1.3.16 0016787 P62136 29156132 402 SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA 6alz B 2.208 BS03 BKM B 1 R96 C127 S129 Y134 V195 R221 V250 Y272 F276 R91 C122 S124 Y129 V190 R216 V245 Y267 F271 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D59 H61 D87 D90 R91 N119 H120 H168 R216 H243 3.1.3.16 0016787 P62136 29156132 403 SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA