5ztn A 2.496 BS01 CUR A 1 K153 F160 A176 K178 E193 I212 F228 L230 L231 L282 I294 D295 K94 F101 A117 K119 E134 I153 F169 L171 L172 L223 I235 D236 D275 K277 N280 D295 S312 D216 K218 N221 D236 S253 2.7.12.1 0004672,0004712,0005524,0006468 ic50=5nM -logKd/Ki=8.30, IC50=5nM Q92630 29987021 501 GVDLGTENLYFQSMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR 5ztn B 2.496 BS01 CUR B 1 F160 A176 K178 E193 I212 F228 L230 L231 S232 L282 I294 D295 F101 A117 K119 E134 I153 F169 L171 L172 S173 L223 I235 D236 D275 K277 N280 D295 S312 D216 K218 N221 D236 S253 2.7.12.1 0004672,0004712,0005524,0006468 ic50=5nM Q92630 29987021 501 GVDLGTENLYFQSMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR