5zmd A 3.3 BS01 dna B 0 I85 K86 K88 P93 R96 Y108 L109 N110 P213 Y214 K216 S229 W230 H231 E234 I49 K50 K52 P57 R60 Y72 L73 N74 P147 Y148 K150 S163 W164 H165 E168 1.14.11.-,1.14.11.53 0001659,0005634,0005654,0005737,0005829,0005886,0006307,0008198,0010883,0016180,0016607,0016706,0016740,0035515,0035516,0040014,0042245,0043231,0044065,0046872,0051213,0060612,0061157,0070350,0090335,1990931,1990984 Kd=3.69uM Q9C0B1 30718435 2 ~ 10 EFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIKGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHKHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQ 5zmd A 3.3 BS02 dna D 0 Y214 S277 W278 K306 Y148 S194 W195 K223 1.14.11.-,1.14.11.53 0001659,0005634,0005654,0005737,0005829,0005886,0006307,0008198,0010883,0016180,0016607,0016706,0016740,0035515,0035516,0040014,0042245,0043231,0044065,0046872,0051213,0060612,0061157,0070350,0090335,1990931,1990984 Kd=3.69uM Q9C0B1 30718435 2 ~ 10 EFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIKGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHKHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQ 5zmd A 3.3 BS03 MN A 1 H231 D233 H307 H165 D167 H224 1.14.11.-,1.14.11.53 0001659,0005634,0005654,0005737,0005829,0005886,0006307,0008198,0010883,0016180,0016607,0016706,0016740,0035515,0035516,0040014,0042245,0043231,0044065,0046872,0051213,0060612,0061157,0070350,0090335,1990931,1990984 Q9C0B1 30718435 1001 EFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIKGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHKHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQ 5zmd C 3.3 BS01 dna B 0 K88 S277 W278 K306 K52 S192 W193 K221 1.14.11.-,1.14.11.53 0001659,0005634,0005654,0005737,0005829,0005886,0006307,0008198,0010883,0016180,0016607,0016706,0016740,0035515,0035516,0040014,0042245,0043231,0044065,0046872,0051213,0060612,0061157,0070350,0090335,1990931,1990984 Kd=3.69uM Q9C0B1 30718435 2 ~ 10 EFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIKGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAADEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHKHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQ 5zmd C 3.3 BS02 dna D 0 I85 K86 K88 P93 R96 Y108 L109 K216 M226 V228 S229 W230 H231 E234 R459 T463 I49 K50 K52 P57 R60 Y72 L73 K149 M159 V161 S162 W163 H164 E167 R355 T359 1.14.11.-,1.14.11.53 0001659,0005634,0005654,0005737,0005829,0005886,0006307,0008198,0010883,0016180,0016607,0016706,0016740,0035515,0035516,0040014,0042245,0043231,0044065,0046872,0051213,0060612,0061157,0070350,0090335,1990931,1990984 Kd=3.69uM Q9C0B1 30718435 2 ~ 10 EFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIKGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAADEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHKHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQ 5zmd C 3.3 BS03 MN C 1 H231 D233 H307 H164 D166 H222 1.14.11.-,1.14.11.53 0001659,0005634,0005654,0005737,0005829,0005886,0006307,0008198,0010883,0016180,0016607,0016706,0016740,0035515,0035516,0040014,0042245,0043231,0044065,0046872,0051213,0060612,0061157,0070350,0090335,1990931,1990984 Q9C0B1 30718435 1001 EFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIKGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAADEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHKHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQ 5zmd E 3.3 BS01 dna F 0 I85 K86 K88 L90 P93 R96 Y108 L109 N110 K216 M226 V228 S229 H231 E234 R459 I460 I49 K50 K52 L54 P57 R60 Y72 L73 N74 K145 M155 V157 S158 H160 E163 R356 I357 1.14.11.-,1.14.11.53 0001659,0005634,0005654,0005737,0005829,0005886,0006307,0008198,0010883,0016180,0016607,0016706,0016740,0035515,0035516,0040014,0042245,0043231,0044065,0046872,0051213,0060612,0061157,0070350,0090335,1990931,1990984 Kd=3.69uM Q9C0B1 30718435 2 ~ 10 EFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIKGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKKHTEAEIAAACETFLKLNDYLQIETIQALEELAAVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHKHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRG 5zmd E 3.3 BS02 dna H 0 S277 W278 K306 S189 W190 K218 1.14.11.-,1.14.11.53 0001659,0005634,0005654,0005737,0005829,0005886,0006307,0008198,0010883,0016180,0016607,0016706,0016740,0035515,0035516,0040014,0042245,0043231,0044065,0046872,0051213,0060612,0061157,0070350,0090335,1990931,1990984 Kd=3.69uM Q9C0B1 30718435 2 ~ 10 EFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIKGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKKHTEAEIAAACETFLKLNDYLQIETIQALEELAAVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHKHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRG 5zmd E 3.3 BS03 MN E 1 H231 D233 H307 H160 D162 H219 1.14.11.-,1.14.11.53 0001659,0005634,0005654,0005737,0005829,0005886,0006307,0008198,0010883,0016180,0016607,0016706,0016740,0035515,0035516,0040014,0042245,0043231,0044065,0046872,0051213,0060612,0061157,0070350,0090335,1990931,1990984 Q9C0B1 30718435 1001 EFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIKGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKKHTEAEIAAACETFLKLNDYLQIETIQALEELAAVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHKHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRG 5zmd G 3.3 BS01 dna F 0 Y214 W278 K306 Y150 W196 K224 1.14.11.-,1.14.11.53 0001659,0005634,0005654,0005737,0005829,0005886,0006307,0008198,0010883,0016180,0016607,0016706,0016740,0035515,0035516,0040014,0042245,0043231,0044065,0046872,0051213,0060612,0061157,0070350,0090335,1990931,1990984 Kd=3.69uM Q9C0B1 30718435 2 ~ 10 EFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIKGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHKHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQ 5zmd G 3.3 BS02 dna H 0 I85 K86 K88 L90 P93 R96 Y108 L109 N110 P213 Y214 L215 K216 V228 S229 W230 H231 E234 I49 K50 K52 L54 P57 R60 Y72 L73 N74 P149 Y150 L151 K152 V164 S165 W166 H167 E170 1.14.11.-,1.14.11.53 0001659,0005634,0005654,0005737,0005829,0005886,0006307,0008198,0010883,0016180,0016607,0016706,0016740,0035515,0035516,0040014,0042245,0043231,0044065,0046872,0051213,0060612,0061157,0070350,0090335,1990931,1990984 Kd=3.69uM Q9C0B1 30718435 2 ~ 10 EFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIKGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHKHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQ 5zmd G 3.3 BS03 MN G 1 H231 D233 H307 H167 D169 H225 1.14.11.-,1.14.11.53 0001659,0005634,0005654,0005737,0005829,0005886,0006307,0008198,0010883,0016180,0016607,0016706,0016740,0035515,0035516,0040014,0042245,0043231,0044065,0046872,0051213,0060612,0061157,0070350,0090335,1990931,1990984 Q9C0B1 30718435 1001 EFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIKGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHKHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQ